Clinical Research Fellow

An exciting opportunity has arisen within the Research and Innovation Division at The Christie. We are looking to appoint a Senior Clinical Fellow in Translational Research to provide medical support to the MANIFEST Consortium (Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity) within The Christie NHS Foundation Trust.

This is a 10 session non-training post, funded through The Christie NHS Foundation Trust for up to 2 years. The role is suitable for individuals ideally having completed at specialist training in Medical Oncology, but those at the end of IMT training may also be considered.

The position requires an ability to understand and deliver translational research, liaising across a range of clinical, academic and administrative staff throughout the Trust and with external organisations (pharmaceutical and biotech industry partners, academic institutions and other hospitals). It is expected the successful applicant will publish a number of papers as a result of their attachment, and there will be an opportunity to develop novel research projects.

To work as a Senior Clinical Fellow in Translational Research at the Christie under the supervision of Professor Samra Turajlić and Dr Jonathan Lim. This will involve close liaison with other members of the multidisciplinary team in particular surgeons, research nurses and data managers.

To work closely with and support the team in the management of patients with enrolled in MANIFEST study. An important role of the Clinical Fellow will be to have direct involvement in the day-to-day clinical management of patients under the supervision of the consultant whether or not they are being managed within the confines of a clinical trial, and to attend relevant MDTs, radiology and educational meetings.

The Clinical Fellow will be required to support research and NHS clinics, typically 3 clinics per week. You will be expected to attend Safety Review Committee meetings (usually remotely) to discuss trial patients. This will involve close liaison with the MANIFEST Principal Investigators, disease-site specific consultants across the Trust and other members of the team. In addition, you will interface with external stakeholders such as other NHS, academic and industry partners.

The post does not attract an on-call commitment.

The Christie is one of Europe's leading cancer centres, treating over 60,000 patients a year. We are based in Manchester and serve a population of 3.2 million across Greater Manchester & Cheshire, but as a national specialist around 15% patients are referred to us from other parts of the country.

We provide radiotherapy through one of the largest radiotherapy departments in the world; chemotherapy on site and through 14 other hospitals; highly specialist surgery for complex and rare cancer; and a wide range of support and diagnostic services. We are also an international leader in research, with world first breakthroughs for over 100 years.

We run one of the largest early clinical trial units in Europe with over 300 trials every year. Cancer research in Manchester, most of which is undertaken on the Christie site, has been officially ranked the best in the UK.

DUTIES OF THE POST

• ROLE: The successful candidate will be recruited as a Senior Clinical Fellow in the MANIFEST Team.
• RESEARCH: A diverse range of translational research are in progress within MANIFEST and, following training, the post holder will be expected to participate in these studies as a co-/subinvestigator.

You will be involved in managing all aspects of trial patients, across a diverse range of solid tumours, through new patient consultation, consent and screening patients and reviewing patients at followup

appointments. Primarily, patients are seen in the outpatient setting but with some inpatient cover. The appointee is required to attend 3 trial outpatient clinics per week (see indicative timetable).

You will be expected to attend Safety Review Committee meetings (usually remotely) to discuss trial patients. This will involve close liaison with the MANIFEST Principal Investigators, disease-site specific

consultants across the Trust and other members of the team. In addition, you will interface with external stakeholders such as other NHS, academic and industry partners. You will be expected to attend weekly MANIFEST operational meetings to discuss study oversight

items, quarterly stakeholders meetings, and annual MANIFEST symposium.

• PROTOCOLS: You will be expected to undertake the administrative duties associated with the care of their patients. You will be encouraged to harness opportunities to be involved in the development

and planning of new studies.

• PROFESSIONAL DEVELOPMENT: You will maintain a level of continuing professional development

consistent with the recommendations of the Royal College of Physicians. Appropriate arrangements for study leave will be made in conjunction with colleagues. There is the potential to present research work and the post holder will be expected to be involved in audit, writing papers and

reviews. You will also be required to undergo an annual appraisal.

• TEACHING COMMITMENT:

a) Undergraduate - You will be required to contribute to the undergraduate teaching of medical students on oncology

topics.

b) Postgraduate - Through collaboration with University of Manchester the team supports a busy postgraduate teaching programme and staff are often requested to lecture on relevant topics. You will be expected to contribute actively to the education of junior doctors, specialty trainees and fellows on the team.

You will also be expected to help in the training of nursing and multi-disciplinary staff in both inpatient and outpatient departments.

• CLINICAL GOVERNANCE: You will be expected to participate in all relevant aspects of clinical governance, including maintaining up to date protocols, guidelines and clinical audit, under the supervision of the other consultants in the experimental cancer medicine team.
• AUDIT: You will play a full role in clinical audit as a member of The Christie Medical Staff Committee. You will develop, supervise and deliver team audit projects.