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6 days ago

Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full time £50,000 - £60,000 per year

Overall purpose: 

To work within the group of Dr Joe Yeeles at the MRC Laboratory of Molecular Biology (LMB), within a programme studying the mechanisms of chromosome replication. Specifically, to undertake research to investigate the molecular mechanisms of human replisome assembly, funded by a Wellcome Trust Discovery Award. Replisome assembly is exquisitely regulated to ensure each region of the genome is replicated only once. This project seeks to understand the structural and mechanistic basis of this process using a combination of cutting-edge biochemical reconstitution with yeast and human proteins and structural biology (primarily cryo-EM) 

Main duties:


•    To undertake research aimed at discovering the molecular mechanisms of yeast and human replisome assembly.

•    To identify, develop and apply a broad range of techniques to pursue the research objectives.

•    To present scientific work at seminars within the laboratory and at external meetings.

•    To contribute to laboratory-wide discussions on developments within the field. 

•    To draft scientific papers, and contribute to the overall preparation of research for publication.

•    To contribute to the LMB's mission in the public engagement of science, and the translation of research findings into improvements in health care.

•    To assist in the training of PhD students and other members of the LMB.

Key responsibilities:

Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan.

To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor.

To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

To enhance your research and generic skills through a tailored development programme.

Working relationships: 

You will report to Dr Joe Yeeles and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary.

Additional information:

This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:

•    MRC training courses.

•    External training and personal development courses.

•    One-to-one training with your Supervisor and other Scientists.

You will commit to undertaking the following:

•    Developing and following a personal development plan.

•    Attending training courses.

•    Identifying additional training which will support you to develop your career.

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