Principal Investigator

1 week ago

London, Greater London, United Kingdom Barrington James Full time £80,000 - £120,000 per year

A clinical research site north of London is seeking an experienced Principal Investigator to lead and oversee respiratory clinical studies. The role is ideal for a physician with a strong background in conducting Phase II–IV trials and specific experience working with COPD populations.


• Act as Principal Investigator for respiratory clinical trials, ensuring full compliance with GCP


• Provide medical oversight and safety assessment for study participants


• Supervise study teams, including Sub-Investigators, Nurses, and Study Coordinators


• Review and sign off eligibility assessments, adverse events, medical histories, and study documentation


• Participate in monitoring visits, audits, and sponsor meetings


• Collaborate closely with site leadership to improve recruitment, retention, and data quality


• Support protocol review, feasibility assessments, and site readiness for upcoming respiratory studies

Essential Requirements:


• GMC-registered physician eligible to practice in the UK


• Previous Principal Investigator experience in
5–10 clinical trials
(minimum requirement)


• Hands-on respiratory experience — ideally COPD, asthma, or other pulmonary indications


• Strong understanding of GCP, clinical trial conduct, and safety reporting


• Ability to lead a multi-disciplinary research team and communicate effectively with sponsors/CROs

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