UK - Principal Scientist PKPD Non Clin

1 week ago


Slough, United Kingdom BioTalent Ltd Full time £150 - £200

Principal Scientist – Non-Clinical PKPD (Contract)Considering applying for this job Do not delay, scroll down and make your application as soon as possible to avoid missing out.UK (Slough-based, VDI only – remote access provided) | 12-month contract |Full-time (37.5 hrs/week) | £35.20–£47.92/hr (PAYE/LTD/Umbrella)We are supporting a global biopharma organisation seeking an experienced Principal Scientist, Non-Clinical PKPD to join their Early Clinical Development & Translational Sciences group on a 12-month contract.This role sits within the Quantitative Clinical Pharmacology function, which integrates PK/PD, systems modelling, clinical pharmacology, and DMPK approaches across the full drug development lifecycle. The position offers an excellent opportunity for a skilled pharmacokinetics/pharmacodynamics scientist to contribute to innovative drug development projects from preclinical through regulatory submission.Key ResponsibilitiesLead strategy and execution of non-clinical PKPD and GLP toxicokinetic studies.Provide scientific input into study protocols and regulatory study designs.Collaborate cross-functionally with Non-Clinical Safety, Bioanalysis, Clinical Pharmacology, and external CRO partners.Ensure delivery of high-quality data packages that meet GLP and regulatory submission standards.Analyse, interpret, and report PKPD/toxicokinetic study results; deliver reports and summaries for regulatory submissions.Effectively communicate interim and final results to project teams and stakeholders.Represent the function internally and externally, contributing to scientific reputation and best practices.Candidate ProfilePhD, MSc, or BSc in pharmacology, quantitative pharmacology, pharmacokinetics/pharmacodynamics, DMPK, or related field.5+ years’ hands-on PKPD data analysis experience within pharma or CRO environments.Strong knowledge of pharmacology and drug mechanisms.Proven ability to design and deliver non-clinical PKPD studies and GLP toxicokinetics reports.Proficiency with Phoenix WinNonlin is essential; experience with modelling/simulation tools (e.g., Berkeley Madonna, R) a plus.Track record of regulatory submissions and/or scientific publications desirable.Strong communication skills with the ability to influence and collaborate in a matrix environment.Contract DetailsDuration: 12 months (potential extension).Hours: 37.5 per week (7.5 per day).Location: UK-based; virtual desktop infrastructure (VDI only). xpwpeyx Candidate provides own equipment. Future office relocation to Surrey anticipated in 2026/27.#J-18808-Ljbffr



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