Principal Engineer

OverviewWe are hiring a Principal Engineer to join a new team working on initiatives and projects which will use the Our Future Health resource to provide personalised, actionable health insights (such as basic calculated disease risk scores and more advanced Polygenic and Integrated Risk scores) to participants and enable a large increase in the UK's ability to run clinical trials as part of the government\'s 10-year NHS plan. This role will be pivotal in delivering key technologies that impact participant health on a national scale. Sitting at the intersection of technology oversight, architecture, product development, and clinical software delivery, you will provide the technical direction and expertise needed to design, architect, integrate, operate, and govern internal and third-party digital health technologies. These applications will process sensitive health data, share health insights, enable further third-party research studies, and build participant engagement. You will also play a key role in defining regulatory strategy, contribute to medical risk management, and work with regulatory specialists to understand applicable standards, ensuring compliance by establishing procedures with a focus on Information Security, Health Information, and Medical Device standards.Make sure to apply with all the requested information, as laid out in the job overview below.To fulfil this role, you will need extensive knowledge and experience of digital health applications, clinical trials, genomics, and associated regulatory requirements. You\'ll apply these to drive programme-level outcomes required to meet targets for clinical trial recruitment, returning health insights to participants, and developing necessary regulated software where applicable. At Our Future Health, our mission is to transform the prevention, detection and treatment of conditions such as dementia, cancer, diabetes, heart disease and stroke. We\'re looking for people to join us on our journey. If you\'re looking for a new challenge where you can contribute to helping future generations live in good health for longer, then we\'re keen to speak with you.ResponsibilitiesLead the technical design, development, and delivery of precision medicine / personalised health software products or devicesManage large-scale processing and management of sensitive health data, focused on healthcare delivery and clinical trialsCollaborate on cloud platform strategy with Azure, AWS or GCPWork with Infrastructure as Code, ideally TerraformApply good data modelling and design patterns; deep knowledge of relational databases (e.g. PostgreSQL) and familiarity with other data stores (blob, document, graph)Provide technical leadership in an agile development team, promoting practices like code review, TDD, CI/CD and pairing using Git and GitHubOversee operational aspects post-live, including observability, logging, metrics, error reporting, debugging and live incident managementCollaborate with cross-functional teams of engineers, product, UX and non-technical stakeholdersLead work across multiple cross-functional teams to deliver overall objectivesFacilitate complex technical discussions with organisation-wide impact, encouraging collaboration and directionCommunicate with stakeholders at various levels, including exec level (CTO, CPO, etc)Develop Software as a Medical Device (SaMD) in compliance with UK MDR 2002 and applicable international standards (ISO 14971, ISO 13485, IEC 62304, IEC 62366)Produce and maintain required software lifecycle documentation under IEC 62304 (e.g., software development plans, architecture and design specs, test protocols and reports, traceability matrices)Maintain quality management systems (ISO 13485), participate in internal audits, CAPA processes, and ensure software lifecycle documentation is inspection-ready for regulatory reviewApply risk management per ISO 14971 and usability engineering per IEC 62366Understand clinical safety and health software standards relevant in the UK (e.g. DCB0129/0160) and regulatory expectations for safe deployment of clinical softwareSupport regulatory submissions (Technical Files, Design Dossiers, or equivalent) and respond to regulator/Approved Body queries on software documentationExperience working in small, growing organisations with ambiguity, where flexibility is valuedDemonstrate software quality excellence and lead quality improvement initiatives across cross-functional teamsMentor engineers across experience levelsQualificationsExtensive experience in digital health, clinical trials, genomics, and regulatory requirementsProven track record in technical leadership and delivering regulated software productsBenefitsGenerous Pension Scheme - employer contributions up to 12%30 Days Holiday + Bank HolidaysEnhanced Parental LeaveCycle to Work SchemeHome & Tech Savings£1,000 Employee Referral BonusWellbeing Support and 24/7 online GP servicesFlexible and remote working arrangementsJoin us - let\'s prevent disease together.At Our Future Health, we recognise the importance of having a diverse workforce and ensure equitable access to our application process. xpwpeyx We encourage applicants who identify as having a disability, neurodiversity, or long-term health conditions to request reasonable adjustments as part of the application process. If you require adjustments, please email #J-18808-Ljbffr