Principal Scientist Translational Science – Neurodegeneration or Renal Disease

As a Principal Scientist in the Translational Unit, working in Neurodegeneration or Renal Disease, you will play a critical role in bridging preclinical and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, and biofluids. This is a lab-based position with mandatory on-site presence at either the Upper Providence, Pennsylvania (USA) or Stevenage (UK) laboratory sites. Design and execute laboratory experiments to advance scientific understanding and support drug discovery in neurodegeneration or renal disease. Support identification and validation of clinical biomarkers and development of clinically deployable biomarker assays. Apply expertise in multiple capabilities such as ELISA / MSD / Quanterix, Western / JESS, flow cytometry, gene / protein expression analysis, proteomics, and other omics platforms. Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design. Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines. Basic Qualifications : PhD in a scientific discipline (e.g., Molecular Biology, Genetics, Immunology, or related field) with relevant laboratory experience. 4+ years’ experience in translational and biomarker development. Experience with handling of primary human cells and laboratory techniques such as immunoassays (ELISA, MSD, Quanterix), multi-color flow cytometry, and gene expression analysis. Experience in renal disease or neurodegeneration disease areas. Preferred Qualifications : Excellent problem-solving skills and ability to critically analyze scientific data. Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner. Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards. Able to independently define strategic approach to tackle specific project or department goals. Ability to work independently as well as collaboratively in a team-oriented environment. Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities. Please visit to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas : respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses / Agencies GSK does not accept referrals from employment businesses and / or employment agencies in respect of the vacancies posted on this site. All employment businesses / agencies are required to contact GSK's commercial and general procurement / human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business / agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business / agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK does not accept referrals from employment businesses and / or employment agencies in respect of the vacancies posted on this site. All employment businesses / agencies are required to contact GSK's commercial and general procurement / human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business / agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business / agency shall be deemed to have been performed without the consent or contractual agreement of GSK. #J-18808-Ljbffr