Senior Bioinformatics Specialist

3 weeks ago

Oxford, Oxfordshire, United Kingdom EIT Pathogena Full time

About EIT Pathogena

EIT Pathogena is a pioneering research and development facility that leverages advanced technology to tackle humanity's most pressing challenges. Guided by world-leading scientists and entrepreneurs, we drive innovation by pushing the boundaries of scientific and technological advancements in four key areas: health and medical science, food security and sustainable agriculture, climate change and clean energy, and government innovation and artificial intelligence.

Our new interdisciplinary research and development facility, EIT Oxford, bridges The Oxford Science Park and Littlemore. This state-of-the-art facility will feature 30,000m2 of research laboratories, an oncology and preventative care clinic, and educational and meeting spaces. EIT Oxford will further our partnership with the University of Oxford and become the new home for Ellison Scholars.

We believe that a collaborative team atmosphere is essential to our mission. We strive to create a supportive environment where everyone feels empowered to take creative risks and innovate. We value emotional intelligence, empathy, and respect for others. Our team is curious, committed, and resilient, with a deep sense of responsibility and a drive for excellence.

The Pathogena Mission

The EIT Pathogena Mission aims to revolutionize the diagnosis and treatment of infectious diseases by developing Whole Genome Sequencing-based metagenomic and individual pathogen clinical tools. Our ultimate goal is to establish an 'always-on global pathogen metagenomics system' that can identify Pathogen X and provide early warning of disease epidemics.

Built by a world-leading pathogen genomics team from the University of Oxford, supported by Oracle Inc's cloud computing scale and security, the Pathogena Mission is designing a global, turn-key solution that systematizes how genomic sequencing data is processed. We aim to develop pipelines to analyze a broad range of pathogens and deliver solutions to laboratories, hospitals, and public health organizations worldwide.

The Role

We are seeking an exceptional Bioinformatics Research Scientist to contribute to the development, evaluation, and deployment of groundbreaking bioinformatic solutions within a real-world context. As a key member of our team, you will engage closely with our partners at the University of Oxford, demonstrating a mission-driven attitude and adaptability to fulfill our collective objectives. Your contributions will be valued and encouraged, as we seek your input on enhancing our offerings, platform, and operational practices.

Key Responsibilities

  • Develop code, implement, and evaluate computational/bioinformatic methods and tools to support research and development in infectious disease genomics, including species prediction, AMR determination, and outbreak and relatedness information.
  • Create analysis pipelines and validate various tools' performances.
  • Understand various sequencing devices and data types, as well as have a good understanding of upstream laboratory processes.
  • Be familiar with current genomic repositories such as ENA, GenBank, GISAID, etc.
  • Collaborate with cross-functional teams, including academics, clinicians, computer scientists, biostatisticians, and biologists, to develop and implement data-driven strategies.
  • Stay up-to-date on the latest developments in bioinformatics and computational biology.
  • Be innovative and take the initiative to introduce new ideas and approaches.
  • Manage and mentor team members, setting performance goals and providing regular feedback.

Requirements

We are looking for someone with:

  • A PhD qualification in computer science, bioinformatics, computational biology, microbiology, mathematics, genetic epidemiology, genomics, machine learning, or equivalent.
  • Strong programming skills in languages such as Bash, Python, R, Nextflow, Snakemake, etc.
  • Experience in infectious disease genomic analysis.
  • A scientific understanding of infectious disease genomics.
  • 3-5+ years of experience in bioinformatics and computational biology.
  • An established or upcoming bioinformatic publication history.
  • Experience with large-scale genetic data analysis using bioinformatics tools and pipelines.
  • Proven leadership and management skills and excellent communication skills.
  • Ability to work effectively in a high-growth, fast-paced, dynamic environment.

Nice to Haves

  • Experience using Docker and working with cloud computing.
  • Experience with regulatory guidelines and systems, e.g. FDA, CE, UKCA, EUCAST.
  • Familiarity with machine learning and data visualization techniques.
  • Experience working in a biotech or pharma industry setting.
  • A track record of launching an academic product in the commercial market.

Benefits

We offer a competitive salary reviewed annually based on performance and market rates, a bonus scheme participation, travel allowance, enhanced sick pay and maternity/paternity after qualifying service, access to Employee Assistance Programme and online and virtual therapy services, employer-funded Private Medical Insurance and Hospital Cash Plan, access to Perk Box for high street and online savings, as well as other discounts and benefits, pension salary sacrifice scheme, minimum 5% employee and 7.5% from employer, group life cover 4 times annual base salary, group income protection plan, and 25 days of holiday per year plus public holiday, with the option to purchase up to five additional days.

Location

Oxford, UK/remote blend, with an office based on Oxford Science Park and some remote working.

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