Research and Development Specialist

2 days ago

Oxford, Oxfordshire, United Kingdom Exscientia Full time

About Exscientia

We're a precision medicine company that leverages AI-driven technology to discover, design and develop innovative drugs at an unprecedented pace. Our cutting-edge platform has successfully guided treatment selection and improved patient outcomes in a prospective interventional clinical study.

Our team is dedicated to pioneering a new approach to medicine creation, where the best ideas of science rapidly become the best medicines for patients. With a focus on oncology, our internal pipeline aims to revolutionize drug discovery timelines and bring treatments to patients faster.

The Role

We're seeking a Research and Development Specialist to join our state-of-the-art automated laboratory focused on chemical synthesis, compound management, and biology. You'll be responsible for developing and operating analytical and purification tools, supporting our fully automated synthesis capability and the needs of our synthetic chemistry team.

Your Key Responsibilities

  • Implement new technology to support automated analytical and purification workflows.
  • Collaborate with ADME experts to measure physicochemical parameters such as Chrom logD and EPSA.
  • Deliver rapid achiral and chiral purification processes for both automated and conventional synthesis workflows.
  • Support automated QC and quantitation workflows using LC-MS and Charged Aerosol Detection.
  • Collaborate with internal and external stakeholders to implement customised software or AI solutions for data manipulation and exploitation.
  • Stay up-to-date with world-class scientists and learn from their expertise to inform your work and broaden your knowledge.

Requirements

Essential Skills:

  • BSc qualification in Chemistry or Pharmaceutical Science, with at least 6 months industrial or academic experience in Separation Science.
  • Proficiency in analytical LC-MS and/or SFC-MS, with a basic understanding of chirality and isomer separation strategies within drug discovery. Proficiency in operating mass and/or UV guided purification systems.
  • Able to apply separation science to solve complex problems and troubleshoot LC-MS instruments.
  • Innovation mindset with an open-minded attitude to drug discovery technologies and enthusiasm to challenge the status quo.
  • Ability to work in high-performing, cross-functional teams with a collaborative mindset.
  • Strong written and verbal communication skills, with regular interactions with various teams and presentation of data to colleagues.

Desirable Skills:

  • Experience with batch/plate analysis and automating data processing workflows for QC applications. Experience with alternative detection techniques for compound quantification.
  • Experience with physicochemical parameter measurement using HPLC and SFC methodologies.

What We Offer

Salary: £60,000 - £80,000 per annum, depending on experience.

Benefits:

  • Competitive salary and annual bonus.
  • Comprehensive private health insurance, dental and vision benefits.
  • Pension scheme and life cover.
  • Generous holiday allowance and flexible working options.
  • Four-week paid sabbatical after four years of service.
  • Progressive leave policies, including parental, fertility, menopause and family emergency leave.
  • Childcare costs assistance for children aged 0-5 through our affordable childcare scheme.
  • Two generous salary exchange schemes for discounts on electric vehicles and cycling equipment.

Join Our Team

At Exscientia, we're committed to building a diverse, equitable, and inclusive environment where every employee belongs. We value and celebrate the diversity of our team, recognising that our differences drive our creativity and innovation forward.

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