Senior Quantitative Pharmacologist

2 days ago

Cambridge, Cambridgeshire, United Kingdom Pfizer Full time

This is an exciting opportunity to contribute to the development of model-informed drug development (MIDD) plans for assigned projects at Pfizer. The successful candidate will work closely with partners to optimize prospective studies, inform drug development strategy, and project decision-making.



Key Responsibilities:


  • Conduct and report quantitative analyses integrating pharmacokinetics, pharmacodynamics, patient characteristics, and disease states to optimize doses, dosage regimens, and study designs throughout all phases of clinical drug development.
  • Identify opportunities where MIDD approaches can advance the understanding of pharmacological activity, efficacy, and safety.
  • Provide support in the development and application of state-of-the-art quantitative methodologies, pharmacometrics tools, software, hardware, and related business processes.
  • Collaborate with multidisciplinary development teams, including clinical pharmacologists, clinicians, and statisticians, to create MIDD plans that include assessments of a drug's efficacy, safety, and commercial viability.
  • Execute relevant quantitative analyses, including population pharmacokinetics, pharmacokinetics/pharmacodynamics, exposure response, disease progression modeling, model-based meta-analysis, quantitative knowledge management, and decision analysis.
  • Prepare formal presentations and written reports to Pfizer standards.
  • Contribute to regulatory documents, including summary documents, briefing books, and regulatory responses.
  • Stay up-to-date with literature, government guidelines, and internal guidance as relates to pharmacometrics and MIDD, including internal SOPs and regulations.
  • Contribute to the development or improvement of tools, processes, and methodology, including involvement in internal cross-functional workgroups or initiatives, external alliances, or committees, consortia, and academic relationships.


Requirements:


  • PhD in Pharmacometrics, Clinical Pharmacology, Pharmacokinetics, Engineering, Pharmaceutical Sciences, or PharmD.
  • Strong quantitative modeling skills, including pharmacometrics, pharmacokinetics, mechanistic modeling/systems pharmacology, and statistics.
  • Experience with R software.
  • Strong communication skills, including written, oral, and presentation skills.
  • Industry experience in Pharmacometrics, Clinical PK/PD, and/or Clinical Pharmacology.
  • Experience with Nonmem, PsN, MATLAB, or other pharmaceutical software.
  • Experience with other statistical software, such as Stan.
  • Programming experience, including Python and C++.


Working at Pfizer:

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status.



Pfizer is an E-Verify employer and requires permanent work authorization in the United States.



This position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share-based long-term incentive program.



We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and support each of life's moments.



Learn more at Pfizer's Candidate Site – U.S. Benefits.

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