Senior Radiochemist

3 weeks ago

London, Greater London, United Kingdom Kings College London Full time
Job Summary

The Senior Production/QC Radiochemist will play a key role in the production and quality control of radiopharmaceuticals at the PET Centre, part of Kings College London. This is a full-time position with an indefinite contract, requiring a strong background in radiochemistry and experience with GMP compliance.

Main Responsibilities
  • Develop new tracers through practical validation work, ensuring compliance with GMP procedures.
  • Support GMP compliance by performing practical validation work and updating SOPs as directed by senior radiochemists.
  • Train other staff members in production and QC processes, and act as the point of contact between the PET production/QC team and the clinical team as needed.
  • Undertake commissioning, validation, production, and QC analysis of PET radiotracers in accordance with GMP procedures.
  • Perform routine tests, inspections, and maintenance on laboratory equipment and infrastructure.
  • Ensure accurate records are maintained of all production, QC, tests, inspections, and maintenance work in accordance with SOPs.
  • Participate in a production and QC rota system to cover assigned duties, with flexibility to adapt to changing service needs.
  • Comply with local rules for working in a controlled area and follow strict aseptic techniques when working in the isolator hot-cell.
  • Communicate technical problems with equipment or processes to other team members, cyclotron engineers, clinicians, and senior staff.
  • Update and write SOPs, logs, and records as necessary, and investigate quality exceptions.
Person Specification

Knowledge and Skills

  • Proven record of adhering to the principles of GLP and GMP.
  • Ability to amend documents, such as SOPs.
  • Excellent verbal and written communication skills.
  • Excellent time-keeping, reliability, flexibility, and ability to work with a variety of people.

Experience

  • Knowledge of PET radiotracer synthesis and QC.
  • Radiochemistry/radiopharmacy laboratory experience.
  • Practical experience with the production and/or QC of PET radiopharmaceuticals.

Desirable

  • Knowledge of Ionising Radiation protection regulations.
  • Experience with automated synthesis equipment.
  • Experience of production to GMP standards.

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