Clinical Pharmacology Modelling and Simulation Lead

4 weeks ago

Stevenage, Hertfordshire, United Kingdom GSK Full time
Job Description

At GSK, we are seeking a highly skilled Clinical Pharmacology Modelling and Simulation Lead to join our team in the Department of Clinical Pharmacology Modelling and Simulation (CPMS). This is an exciting opportunity for a quantitative clinical pharmacologist with a strong background in Respiratory & Immunology to advance the vision and mission of GSK's rapidly expanding Respiratory & Immunology portfolio.

The successful candidate will play a critical role in driving integration of end-to-end model-informed drug discovery and development. They will be accountable for defining, coordinating, and defending Clinical Pharmacology Modelling & Simulation development strategies for disease & therapeutics of interest at senior level meetings. Additionally, they will provide expert input into the clinical pharmacology evidence generation and integrated evidence plans.

This is a hybrid role that combines modelling/simulation with clinical impact, touching the whole life cycle from first in human and beyond. It's a chance to join a highly successful and well-recognized team in the broader industry, reputed for their impact and publications success.

Key Responsibilities
  • Establish or guide mathematical model development to understand disease, its progression, and drug action to prevent, treat, and cure diseases.
  • Define and execute a coordinated scientific and technical strategy with demonstrated ability to coordinate outputs from several expertise areas to determine strategy.
  • Build and utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways, and progression, as well as drug candidates or treatment modalities.
  • Work in close collaboration with bench biologists, data scientists, computational biologists, clinicians, and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms.
  • Develop and/or utilize state-of-the-art mathematical tools to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction.
  • Create a collaboration framework with internal and external experts in the development and application of these models.
  • Learn and apply emerging modeling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; collaborate with external field-leading teams for methodology application.
  • Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline.
Why GSK?

GSK is a global biopharma company with a special purpose – to unite science, technology, and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive.

We prevent and treat disease with vaccines, specialty, and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology, and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, color, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status, or any other federal, state, or local protected class.*

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.

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