Quantitative Systems Pharmacology Expert
4 weeks ago
We are seeking a highly motivated and experienced Director-level Quantitative Systems Pharmacology (QSP) Expert to join our team supporting oncology therapeutic area as part of the global Clinical Pharmacology Modelling and Simulation (CPMS) department.
Key Responsibilities:- Develop, guide and apply QSP models to guide clinical study designs and mechanistic interpretation of study results in support of development of treatments and combination of treatments for a variety of diseases and therapeutic areas.
- Integrate and share data and knowledge in a highly stimulating, collaborative, and multi-disciplinary environment to develop a deeper understanding of physiological systems and disease mechanisms within and across therapeutic areas.
- Promote model-informed drug discovery & development (MID3) strategies and approaches by publishing in peer-reviewed journals and presenting at scientific conferences.
- Identify opportunities in collaboration with the CPMS Project Leads where QSP and mechanistic modeling approaches can bring a unique angle to inform project decisions and address project questions in alignment with the CPMS MID3 strategy.
- Scope those QSP opportunities for MID3, and gain engagement from the project team members and decision stakeholders.
- Serve as QSP modeling & simulation point-of-contact in multidisciplinary project teams to solve challenging problems in drug research and development; contribute to preclinical and clinical study design and mechanistic interpretation of data.
- Ensure that QSP simulations and analyses can be translated into actionable insights, learnings, or recommendations for the clinical project team, and communicate those effectively to the project team members and decision stakeholders.
- Innovate by keeping abreast of emerging modelling and simulation methodologies, participating actively in internal and external QSP professional community events and initiatives, and seeking diversity of thought within interdisciplinary teams.
- Continually educate stakeholders on the advantages and limitations of QSP approaches, and promote MID3 by publishing in peer-reviewed journals and presenting at scientific conferences.
- PhD in Applied Mathematics, Engineering or Pharmaceutical Sciences.
- Experience in developing and applying QSP approaches to drug discovery and development programs in the pharmaceutical industry.
- Computational and hands-on experience with one or more modeling and simulation packages or programming languages (e.g., MATLAB, R, Julia, SimBiology, C/C++).
- Experience of common tools for quantitative clinical pharmacology such as NONMEM, R, WINNONLIN, Simcyp, SAS.
- Experience in clinical pharmacology and its utility in drug development, including pharmacokinetics, pharmacodynamic and pharmacometrics approaches, and model-informed drug discovery & development.
- Experience with line management of junior scientists.
- Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-sound PK-PD models.
- Ability to translate, condense, summarize outcomes of modeling and simulation analyses into information that can be understood and invested by project teams.
- Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of mechanistic PK-PD.
- Ability to build effective collaboration while taking personal accountability for delivery of quantitative clinical pharmacology results.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive.
We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at US Toll Free) or outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles.
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