Genomic Oncology Research Leader

2 weeks ago

Stevenage, Hertfordshire, United Kingdom 1925 GlaxoSmithKline LLC Full time

At 1925 GlaxoSmithKline LLC, we are seeking a highly skilled and experienced individual to lead our team as an Associate Director of Oncology Genomics.


The successful candidate will have a key role in the analysis of large-scale somatic genomic and clinical data, applying cutting-edge algorithms and developing automated methods to support large-scale bioinformatics analysis. They will be involved in the processing and analysis of NGS data (with a focus on WES/WGS, SNVs/CNVs, ctDNA) and will need a solid understanding of computational approaches for cancer genome analysis and cancer biology to derive meaningful and reproducible biological insights.


Key Responsibilities:



  2. Process and analyze large-scale somatic genetic datasets (WES/WGS, SNVs, CNVs) and integrate with clinical/phenotypic datasets to derive biological insights.
  3. Develop automated methods to support large-scale somatic genetic, bioinformatics analyses and collaborate closely with other teams (statistical genetics/AIML) to develop advanced algorithms and models.
  4. Integrate complex molecular data (e.g., transcriptomics, proteomics, metabolomics) to derive insights and understand the underlying biology.
  5. Lead multidisciplinary teams effectively to answer complex scientific questions.
  6. Communicate complex ideas and concepts to a range of stakeholders, including peers and leaders.
  7. Collaborate with cross-functional teams to support the development and implementation of oncology genomics strategies.
  8. Stay up-to-date with the latest advancements and trends in oncology genomics and molecular data integration.
  9. Evaluate and implement new methodologies and technologies to improve the efficiency and effectiveness of data analyses.
  10. Foster a culture of collaboration, innovation, and continuous learning within the team.
  11. Ensure compliance with relevant regulations and guidelines in the field of oncology genomics.

Why You?


As a highly skilled and experienced professional, you will be responsible for leading our team in the analysis of large-scale genomic data. You will have a key role in developing automated methods to support large-scale bioinformatics analysis and will be involved in the processing and analysis of NGS data.


Basic Qualifications:



  2. Ph.D. in a quantitative subject, e.g., bioinformatics, biostatistics, computational biology, or epidemiology, with 8+ years of combined academic and industry experience.
  3. 3+ years of programming skills experience (e.g., Bash, R, Python) and bioinformatics tools (bcftools) and workflow management systems (e.g., nextflow).
  4. 3+ years of experience in processing and analysis of large-scale genomic datasets, genetic data analysis, including SNVs/CNVs, WES/WGS, and data interpretation through integration with clinical/phenotypic information.
  5. 3+ years of experience in cancer research, including a deep understanding of computational approaches for cancer genome analysis.

Preferred Qualifications:



  2. Proven ability to effectively lead multidisciplinary teams to answer complex scientific questions.
  3. Evidence of independence in leading research projects and of the ability to develop novel statistical or bioinformatics methods.
  4. Advantageous to have experience in complex molecular data integration, such as transcriptomics, proteomics, and metabolomics.
  5. Strong communication skills to convey complex ideas and concepts to a range of stakeholders.
  6. Excellent problem-solving and analytical skills to address complex scientific questions.
  7. Strong collaboration and partnership skills to work effectively with cross-functional teams.
  8. Excellent project management skills with a focus on delivering results.

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