Lentiviral Vector Manufacturing Lead
5 hours ago
We are seeking an experienced and highly skilled Lentiviral Vector Manufacturing Lead to join our Technical Operations team at Orchard Therapeutics
Estimated Salary: £65,000 - £90,000 per annum
The successful candidate will be responsible for leading the development and improvement of upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development.
Main Responsibilities:
- Lead the design, development and improvement of upstream and downstream processes for LVVs.
- Compile process data, prepare databases to analyse results, confirm scientific hypotheses and/or propose new experiments.
- Prepare, review and complete study reports and protocols/SOPs.
- Assist with CMC and regulatory submissions.
- Contribute to routine lab maintenance.
- Communicate, share and discuss work progress internally and where appropriate with external partners.
Requirements:
- Experience in biotechnology or pharmaceutical industry with a primary focus on the process development and manufacturing of viral vectors, preferably retro and lentiviral vectors.
- Experience in cell line culture techniques and handling of adherent and suspension cell lines in different culture systems, with demonstrated skills in aseptic techniques.
- Knowledge in bioprocessing, purification of viral vectors and virology.
- Use of more specialist lab equipment e.g. bioreactors, AKTA or TFF systems is ideal.
- Proficiency with MS office, MFCS, SnapGene, Unicorn, electronic lab-books and/or other commonly used software.
-
Lead Lentiviral Vector Process Developer
4 days ago
London, Greater London, United Kingdom Orchard Therapeutics Full timeAbout the CompanyOrchard Therapeutics is a global gene therapy company with a diverse and dynamic work environment. Our Technical Development team sits within Technical Operations and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes.We require an experienced Scientist II, Viral Vector...
-
Senior Viral Vector Development Specialist
4 days ago
London, Greater London, United Kingdom Orchard Therapeutics Full timeAbout the RoleOrchard Therapeutics is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSC). We are seeking an experienced Scientist II, Viral Vector Development to join our team in London.The successful candidate will support the...
-
Viral Vector Production Team Lead
4 days ago
London, Greater London, United Kingdom Orchard Therapeutics Full timeAbout the JobAs a Scientist II, Viral Vector Development at Orchard Therapeutics, you will support the Principal Scientist in the development of innovative, high-yield processes for production of lentiviral vectors. You will also compile process data, prepare databases to analyze results, confirm scientific hypotheses, and propose new experiments.Key...
-
Senior Bioprocessing Scientist
5 hours ago
London, Greater London, United Kingdom Orchard Therapeutics Full timeJob Description**Job Title:** Senior Bioprocessing Scientist, Viral Vector DevelopmentEstimated Salary: £60,000 - £80,000 per annumAbout the RoleWe are seeking an experienced Senior Bioprocessing Scientist to join our Technical Operations team at Orchard Therapeutics. The successful candidate will be responsible for supporting the design, development and...
-
London, Greater London, United Kingdom UCL Eastman Dental Institute Full timeAbout the RoleThe Nathwani group at UCL Eastman Dental Institute is a leading research team in gene therapy approaches for various monogenic disorders. We are currently seeking a highly skilled Senior Molecular Biologist to join our team.This role offers an exciting opportunity to contribute to cutting-edge research in gene transfer technologies, including...
-
London, Greater London, United Kingdom Orchard Therapeutics Full timeJob Description:We are seeking a highly motivated Senior Manufacturing Scientist to join our team at Orchard Therapeutics. This is an exciting opportunity to contribute to the development of innovative cell and gene therapies.About the Role:The successful candidate will be responsible for managing, coordinating, and leading manufacturing documentation...
-
Cell Gene Therapies Specialist
4 weeks ago
London, Greater London, United Kingdom Orchard Therapeutics Full timeAbout the RoleWe are seeking a highly skilled Cell Gene Therapies Specialist to join our team at Orchard Therapeutics. The successful candidate will play a key role in supporting the late-phase DS/DP MSAT team and late-phase process development, validation, and maintenance of all DS/DP manufacturing processes.Key ResponsibilitiesSupport commercial GMP...
-
Viral Vector Process Development Specialist
5 hours ago
London, Greater London, United Kingdom Orchard Therapeutics Full timeAbout the JobWe have a fantastic opportunity for a skilled and motivated Viral Vector Process Development Specialist to join our team at Orchard Therapeutics!Salary: £55,000 - £75,000 per annumThe successful candidate will be responsible for designing, developing and improving upstream and downstream processes for LVVs to deliver robust manufacturing...
-
Electrical Installation Lead
3 weeks ago
London, Greater London, United Kingdom Vector Recruitment Solutions Ltd Full timeElectrical Installation Quality Assurance ManagerWe are looking for an experienced Electrical Installation Quality Assurance Manager to join our team at Vector Recruitment Solutions Ltd. In this key role, you will oversee the quality assurance process for electrical installations, ensuring compliance with NICEIC regulations and industry standards. With your...
-
Senior Development Scientist
1 month ago
London, Greater London, United Kingdom Autolus Limited Full timeRole Summary:The post holder will be a highly motivated and organized individual with knowledge of gene and cell therapy, process development, and biotechnology. The individual will be expected to lead a team within the function and contribute to the development of processes suitable for cGMP manufacture of high-quality therapeutic products.Key...
-
Manufacturing Leadership Manager
3 hours ago
London, Greater London, United Kingdom Re:Build Manufacturing LLC Full timeAbout UsAt Re:Build Manufacturing LLC, we're building America's next generation industrial company through a combination of enabling technologies, operational superiority, and strategic partnerships.Our goal is to help revitalize the U.S. manufacturing base over the coming decades, creating substantial opportunities for our employees and the communities...
-
Senior Process Development Scientist
1 month ago
London, Greater London, United Kingdom King's College London Full timeWe are seeking a highly skilled Senior Process Development Scientist to join our team at the King's College London Gene Therapy Vector Facility.The successful candidate will be responsible for the testing and analysis of QC samples generated from the Viral Vectors manufacturing process in process development lab.Key responsibilities will include:Testing...
-
Senior GMP Facilities Manager
3 weeks ago
London, Greater London, United Kingdom BioTalent Full timeGMP Facilities Manager - BioTalentBioTalent has partnered with a gene therapy vector facility in London to find an experienced GMP Facilities Manager.This role plays a key part in translating medical research into clinical therapies for cancer and rare diseases. The successful candidate will contribute to the design, commissioning, and qualification of new...
-
Senior Renewable Energy Systems Specialist
2 months ago
London, Greater London, United Kingdom Vector Recruitment Solutions Ltd Full timeJob DescriptionAbout Vector Recruitment Solutions Ltd :Our client is a leading innovator in renewable energy, providing cutting-edge solutions for sustainable energy management. They focus on delivering renewable energy systems to their clients, improving energy efficiency and reducing their carbon footprint.Job Summary :We are seeking a Senior Field...
-
DNA Manufacturing Quality Assurance Specialist
3 weeks ago
London, Greater London, United Kingdom Touchlight Full timeAbout TouchlightAt Touchlight, we are revolutionizing the field of DNA manufacturing with our innovative dbDNA technology. This groundbreaking approach has been propelled into the spotlight by the rapid growth of RNA and DNA-based vaccines, as well as viral and non-viral cell and gene therapy discovery and development.We believe that DNA is fundamental to...
-
Drainage Solutions Specialist
1 week ago
London, Greater London, United Kingdom Vector Recruitment Solutions Full timeAbout the RoleVector Recruitment Solutions is seeking an experienced Drainage Engineer to join our esteemed client, a leading Maintenance Services Provider in London. This exciting opportunity offers a challenging career path for skilled professionals.Key Responsibilities:Emergency Response: Swiftly respond to emergency and reactive call-outs, addressing...
-
QS Electrical Specialist
3 weeks ago
London, Greater London, United Kingdom Vector Recruitment Solutions Ltd Full timeLead Electrical Installation SpecialistWe require a seasoned Lead Electrical Installation Specialist to join our team at Vector Recruitment Solutions Ltd. In this role, you will be responsible for inspecting and testing electrical installations, ensuring compliance with NICEIC regulations. With your strong diagnostic skills in LV circuits, you will provide...
-
London Drainage Technician
2 days ago
London, Greater London, United Kingdom Vector Recruitment Solutions Ltd Full timeDrainage Engineer Role in LondonJob Overview: Vector Recruitment Solutions Ltd is partnering with a leading Maintenance Services Provider to recruit a skilled Drainage Engineer for their London office.Responsibilities:Perform routine maintenance and inspections on drainage systems.Collaborate with clients to identify and address drainage issues.Design and...
-
Lead Manufacturing Coordinator
2 weeks ago
London, Greater London, United Kingdom Dexters Recruitment Full timeAbout the Role">Dexters Recruitment is seeking a skilled Lead Manufacturing Coordinator to join our client's site in Great Yarmouth. The successful candidate will be responsible for leading the Manufacturing Shift Team to achieve production plans safely and efficiently.">The ideal candidate will have a strong background in manufacturing operations, with...
-
Manufacturing Engineering Lead
2 days ago
London, Greater London, United Kingdom Elevation Recruitment Group Full timeAre you a seasoned manufacturing professional looking for a new challenge?Elevation Recruitment Group has partnered with a leading manufacturing business to recruit a Manufacturing Engineering Lead to join their team in the North West.In this role, you will be responsible for overseeing all aspects of manufacturing engineering, including quality, process...