Lentiviral Vector Manufacturing Lead

5 hours ago


London, Greater London, United Kingdom Orchard Therapeutics Full time
Lead Our Team as a Lentiviral Vector Manufacturing Lead

We are seeking an experienced and highly skilled Lentiviral Vector Manufacturing Lead to join our Technical Operations team at Orchard Therapeutics

Estimated Salary: £65,000 - £90,000 per annum

The successful candidate will be responsible for leading the development and improvement of upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development.

Main Responsibilities:

  • Lead the design, development and improvement of upstream and downstream processes for LVVs.
  • Compile process data, prepare databases to analyse results, confirm scientific hypotheses and/or propose new experiments.
  • Prepare, review and complete study reports and protocols/SOPs.
  • Assist with CMC and regulatory submissions.
  • Contribute to routine lab maintenance.
  • Communicate, share and discuss work progress internally and where appropriate with external partners.

Requirements:

  • Experience in biotechnology or pharmaceutical industry with a primary focus on the process development and manufacturing of viral vectors, preferably retro and lentiviral vectors.
  • Experience in cell line culture techniques and handling of adherent and suspension cell lines in different culture systems, with demonstrated skills in aseptic techniques.
  • Knowledge in bioprocessing, purification of viral vectors and virology.
  • Use of more specialist lab equipment e.g. bioreactors, AKTA or TFF systems is ideal.
  • Proficiency with MS office, MFCS, SnapGene, Unicorn, electronic lab-books and/or other commonly used software.


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