Senior Bioinformatics Scientist

4 weeks ago

London, Greater London, United Kingdom Autolus Limited Full time

Role Summary

We are seeking a highly skilled and motivated Bioinformatician to lead the development and delivery of integrated analyses, including Whole Exome Sequencing (WES), RNA sequencing (RNAseq), clinico-demographic, and biomarker data from patients treated with CAR-T therapy from Autolus' pipeline.

Key Responsibilities

  • Lead the integration of WES, RNAseq, clinico-demographic, and biomarker data from clinical trials and research studies.
  • Develop and implement pipelines and workflows for data processing and integration, ensuring high-quality data management and consistency.
  • Maintain and update databases and data management tools, ensuring data accuracy, security, and compliance with regulatory standards.

Bioinformatics Analysis

  • Perform comprehensive bioinformatics analyses, including variant calling, copy number change, differential expression analysis, pathway analysis, and biomarker discovery in the context of the clinical environment.
  • Utilize statistical and computational tools to interpret multi-omics data and generate meaningful medical and biological insights.
  • Develop and validate predictive models for patient outcomes to CAR-T therapy based on integrated data.

Collaboration and Communication

  • Work closely with cross-functional teams, including clinical, R&D and biostatistics groups, to support data needs and project objectives.
  • Provide bioinformatics expertise and guidance to collaborators, ensuring effective data usage and interpretation.
  • Collaborate with external partners and vendors as necessary to enhance data integration and analysis capabilities.

Scientific Publications

  • Lead the preparation of scientific manuscripts and reports based on integrated data analyses.
  • Contribute to the writing, editing, and submission of scientific publications in high-impact journals.
  • Present findings at scientific conferences, meetings, and internal forums to communicate research outcomes and advance the understanding of CAR-T therapy.

Tool Development and Innovation

  • Develop custom scripts, tools, and software applications to support data integration, analysis, and visualization.
  • Stay abreast of the latest bioinformatics methodologies, technologies, and industry trends to drive innovation and improve data integration processes.

Quality Control and Documentation

  • Ensure quality control of bioinformatics analyses and results, adhering to best practices and standard operating procedures.
  • Document all processes, analyses, and results thoroughly, providing clear and detailed records for reproducibility and regulatory compliance.

Requirements

  • Minimum of 3 years of post-doctoral experience in bioinformatics, with a focus on multi-omics data analysis in a clinical or translational research setting.
  • Exceptional proficiency in statistical analysis and modelling, with a deep understanding of advanced statistical concepts and their applications in translational or clinical biology.
  • Extensive experience with next-generation sequencing data analysis, including WES and RNAseq.
  • Comprehensive understanding of industry standard bioinformatics tools, databases, and best practices.
  • Experience in applying best practices for data management, version control, and reproducible research.

Preferred Qualifications

  • Ph.D. or Master's degree in Bioinformatics, Computational Biology, Genomics, or a related field.

  • Bioinformatics Scientist

    3 days ago

    London, Greater London, United Kingdom Northreach Full time

    Job Title: Bioinformatics ScientistWe are looking for a highly skilled Bioinformatics Scientist to join our team at Northreach. As a key member of our bioinformatics group, you will play a crucial role in advancing genomic research through innovative solutions.Salary: $100,000 - $160,000 per annumJob Description:The ideal candidate will have extensive...

  • Senior Bioinformatics Specialist

    1 month ago

    London, Greater London, United Kingdom The Crick Full time

    Senior Bioinformatics SpecialistWe are seeking a highly skilled Senior Bioinformatics Specialist to join our team at The Crick. As a key member of our Bioinformatics & Biostatistics Scientific Technology Platform, you will work closely with our scientists to analyze complex biological data and develop innovative approaches to drive forward discovery.Key...

  • Senior Bioinformatics Data Scientist

    4 weeks ago

    London, Greater London, United Kingdom BenevolentAI Full time

    We are seeking a highly skilled Senior Bioinformatics Data Scientist to join our Product & Tech division at BenevolentAI. As a key member of our cross-functional team, you will apply cutting-edge approaches to multimodal data integration for drug discovery applications. You will work closely with colleagues in the Informatics function to define and implement...

  • Senior Bioinformatics Research Scientist

    4 days ago

    London, Greater London, United Kingdom Anthony Nolan Full time

    Unlock the Power of Data ScienceWe are seeking a highly skilled Bioinformatics Research Scientist to join our team at Anthony Nolan. As a leading stem cell registry, we are committed to harnessing the power of data science to improve lives and save lives.The successful candidate will play a critical role in developing workflows for the analysis of long-read...

  • Senior Data Scientist

    3 weeks ago

    London, Greater London, United Kingdom BenevolentAI Full time

    We are seeking a skilled Senior Bioinformatics Data Scientist to collaborate with our cross-functional team in the Product & Tech division. This role will involve applying cutting-edge approaches to multimodal data integration for drug discovery applications.Main ResponsibilitiesDomain Expertise: Contribute domain expertise and disseminate best practices in...

  • Senior Bioinformatics Specialist

    1 month ago

    London, Greater London, United Kingdom Oxford Nanopore Technologies Full time

    Job SummaryWe are seeking a highly motivated and driven individual to join our Technical Services team as a Bioinformatics Field Applications Scientist. The successful candidate will have a strong bioinformatics and genomics background, with a dedication to customer service and satisfaction.Key ResponsibilitiesProvide high-quality technical expertise to...

  • Senior Bioinformatics Scientist

    1 month ago

    London, Greater London, United Kingdom Autolus Limited Full time

    Job SummaryWe are seeking a highly skilled and motivated Bioinformatician to lead the development and delivery of integrated analyses, including Whole Exome Sequencing (WES), RNA sequencing (RNAseq), clinico-demographic, and biomarker data from patients treated with CAR-T therapy from Autolus' pipeline. The successful candidate will possess a strong...

  • Bioinformatics Analyst

    4 weeks ago

    London, Greater London, United Kingdom Unreal Gigs Full time

    Unlock the Secrets of Life with Unreal GigsAre you passionate about harnessing the power of technology to drive breakthroughs in health, medicine, and biotechnology? Do you have a knack for analyzing complex biological data and extracting meaningful insights? If you're excited about using computational tools to unravel the mysteries of life, we have the...

  • Senior Bioinformatics Specialist

    1 month ago

    London, Greater London, United Kingdom The Francis Crick Institute Full time

    Job Title: Senior Bioinformatics SpecialistJob Description:The Francis Crick Institute is seeking a highly skilled Senior Bioinformatics Specialist to join its Bioinformatics & Biostatistics Scientific Technology Platform. As a key member of the team, you will work closely with researchers to design and implement advanced bioinformatics and biostatistics...

  • Senior Bioinformatics Specialist

    1 month ago

    London, Greater London, United Kingdom newscientist - Jobboard Full time

    Job Title: Senior Bioinformatics SpecialistAbout the Role:We are seeking a highly skilled Senior Bioinformatics Specialist to join our Bioinformatics & Biostatistics Scientific Technology Platform (STP). As a key member of our team, you will work closely with researchers to design and implement advanced bioinformatics and biostatistics approaches to analyze...

  • Bioinformatics Specialist

    4 weeks ago

    London, Greater London, United Kingdom Unreal Gigs Full time

    Unlock the Secrets of Life with Unreal GigsWe're seeking a talented Bioinformatics Specialist to join our team at Unreal Gigs. As a key member of our team, you'll play a crucial role in analyzing and interpreting complex biological data to drive breakthroughs in health, medicine, and biotechnology.Key Responsibilities:Analyze and Interpret Biological...

  • Senior Bioinformatics Specialist

    1 month ago

    London, Greater London, United Kingdom Francis Crick Institute Full time

    Job SummaryThe Francis Crick Institute is seeking a highly skilled Senior Bioinformatician to join its Bioinformatics & Biostatistics Scientific Technology Platform. As a key member of the team, you will work collaboratively with researchers to design and implement advanced bioinformatics and biostatistics approaches to analyze complex biological data.Key...

  • Senior Bioinformatics Data Analyst

    3 weeks ago

    London, Greater London, United Kingdom BenevolentAI Group Full time

    We are seeking a skilled Senior Bioinformatics Data Scientist to contribute to the Product & Tech division at BenevolentAI. As a key member of a cross-functional team, you will apply cutting-edge data integration approaches to drive drug discovery applications. Collaborating with colleagues in Informatics, you will develop and implement efficient data...

  • Senior Bioinformatics Data Analyst

    4 weeks ago

    London, Greater London, United Kingdom Oho Group Ltd Full time

    Transform Women's Health with UsAt Oho Group Ltd, we're on a mission to revolutionize women's health through innovative health-tech solutions. As a Data Scientist (Bioinformatics) on our team, you'll play a critical role in driving our machine learning initiatives and making a meaningful impact in the industry.We're looking for a highly skilled professional...

  • Bioinformatics Researcher for Therapeutic Gene Editing

    1 week ago

    London, Greater London, United Kingdom SitePoint Pty Full time

    About the RoleWe are seeking a highly analytical and experienced Senior Bioinformatician/Data Scientist to join our research and development team at SitePoint Pty. In this role, you will drive the discovery, development, and curation of gene-editing systems and mobile genetic elements (MGEs) with therapeutic applications.This position offers an exciting...

  • Bioinformatics Expert for Gene Editing and Therapeutic Discovery

    3 days ago

    London, Greater London, United Kingdom Northreach Full time

    Unlock the Potential of Gene Editing and Microbial GenomicsWe are seeking a highly skilled Senior Bioinformatician/Data Scientist to drive our research and development efforts in gene editing and microbial genomics. This exciting opportunity is perfect for an experienced professional looking to make a meaningful impact in the field.About the Role:In this...

  • Senior Bioinformatics Engineer

    4 weeks ago

    London, Greater London, United Kingdom Genomics England Full time

    About the RoleWe are seeking a highly skilled Senior Bioinformatics Engineer to join our team at Genomics England. As a key member of our technical team, you will play a pivotal role in driving the technical excellence of our bio-pipelines service.Key ResponsibilitiesWork alongside product managers, squad engineers, bioinformaticians, and other subject...

  • Data Scientist, Computational Biology

    1 month ago

    London, Greater London, United Kingdom All On Sea Markkleebergersee Full time

    Data Scientist, Computational BiologyJoin All On Sea Markkleebergersee in our mission to innovate drug discovery for unmet medical needs. As a Data Scientist, Computational Biology, you will work with diverse biological data and contribute to our in-house bioinformatics data infrastructure.Key ResponsibilitiesManage complex data science projectsDevelop and...

  • Senior Bioinformatics Lead

    3 weeks ago

    London, Greater London, United Kingdom Autolus Limited Full time

    Role SummaryWe are seeking a highly skilled Bioinformatician to lead the development and delivery of integrated analyses, including Whole Exome Sequencing (WES), RNA sequencing (RNAseq), clinico-demographic, and biomarker data from patients treated with CAR-T therapy from Autolus\' pipeline.Key ResponsibilitiesData Integration and Management• Lead the...

  • High Throughput Screening Bioinformatics Specialist

    2 weeks ago

    London, Greater London, United Kingdom Serna Bio Full time

    About the RoleSerna Bio, a pioneering preclinical drug discovery company, is seeking a skilled Data Scientist to enhance our analytics capabilities and drive research initiatives forward.You will be a key member of our computational biology team, working closely with biology and engineering teams to organize and analyze HTS screening data.Design and execute...