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We are seeking an experienced Phage Display Scientist to join our Protein Binders team at Nxera Pharma. As a key member of our interdisciplinary team, you will utilize your expertise in phage display technology to identify protein binders against therapeutic membrane protein targets.
Key Responsibilities- Employ phage display technology to select protein binders against membrane protein targets
- Screen and validate hits using high-throughput assays, such as ELISA formats, BLI, and cell binding assays
- Subclone plasmid constructs for expression and protein engineering of VHH frameworks
- Biophysically evaluate VHH hits
- Share your expertise, insights, and ideas with the team, project, and department to positively influence project success
- PhD (or MSc/MRes with equivalent lab experience) in a relevant area of biology with demonstrable industry experience carrying out phage display campaigns
- Theoretical and practical expertise in phage display technologies and selection techniques
- Experience working with phage antibody libraries and preferably VHH display
- Strong and evidenced molecular biology proficiency
- Demonstrable expertise in protein-protein interaction screening techniques
- Analytical thinker with good problem-solving skills
- Strong interpersonal skills and ability to interact effectively with scientists across disciplines to generate timely and informative data
- Measuring affinity using either BLI or SPR
- Affinity maturation
- Library build (either affinity maturation or immunised, naïve or synthetic libraries)
- Working with membrane proteins (in particular GPCRs)
- Having computational expertise in protein binder design would be extremely beneficial
Nxera Pharma is a technology-powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs globally. We employ over 350 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland), and Seoul (South Korea) and are listed on the Tokyo Stock Exchange.
We are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies. Our pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI, and immunology, metabolic disorders, and rare diseases.
We leverage the power of our unique and industry-leading GPCR-targeted structure-based drug discovery "NxWave" platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, we have built outstanding capabilities across our platform, discovery, and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development.
In Tokyo, our expert teams are dedicated to late-stage development (Ph 2/3) and innovative commercialization/go-to-market approaches.
Our MissionTo accelerate the development of life-changing medicines, by investing in science and technology.
Our VisionTo lead the next era of medicine. From Japan, for Japan, and the world.
Our Values- Patients, carers, families, and physicians come first
- Innovation and teamwork inspire success
- Focus on top priorities where we can make a difference
- Speed and agility of decision-making
- Operational excellence
