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Director, Quantitative Systems Pharmacology Expert
2 months ago
Job Summary
We are seeking a highly motivated and experienced Director-level Quantitative Systems Pharmacology (QSP) Expert to join our team at GSK. As a key member of our Clinical Pharmacology Modelling and Simulation (CPMS) department, you will play a critical role in delivering CPMS excellence to research and development programs using quantitative pharmacology approaches.
Key Responsibilities
- Develop, guide, and apply QSP models to inform clinical study designs and mechanistic interpretation of study results in support of treatment development and combination therapies for various diseases and therapeutic areas.
- Integrate and share data and knowledge in a collaborative, multi-disciplinary environment to develop a deeper understanding of physiological systems and disease mechanisms within and across therapeutic areas.
- Promote model-informed drug discovery and development strategies and approaches by publishing in peer-reviewed journals and presenting at scientific conferences.
- Identify opportunities to apply QSP and mechanistic modeling approaches to inform project decisions and address project questions in alignment with the CPMS MID3 strategy.
- Scope QSP opportunities for MID3, engage project team members and decision stakeholders, and serve as QSP modeling and simulation point-of-contact in multidisciplinary project teams.
- Contribute to preclinical and clinical study design and mechanistic interpretation of data, ensuring that QSP simulations and analyses can be translated into actionable insights, learnings, or recommendations for the clinical project team.
- Innovate by staying up-to-date with emerging modeling and simulation methodologies, participating in internal and external QSP professional community events, and seeking diversity of thought within interdisciplinary teams.
- Continually educate stakeholders on the advantages and limitations of QSP approaches and promote model-informed drug discovery and development by publishing in peer-reviewed journals and presenting at scientific conferences.
Requirements
- PhD in Applied Mathematics, Engineering, or Pharmaceutical Sciences.
- Experience in developing and applying QSP approaches to drug discovery and development programs in the pharmaceutical industry.
- Computational and hands-on experience with one or more modeling and simulation packages or programming languages (e.g., MATLAB, R, Julia, SimBiology, C/C++).
- Experience with common tools for quantitative clinical pharmacology, such as NONMEM, R, WINNONLIN, Simcyp, and SAS.
- Experience in clinical pharmacology and its utility in drug development, including pharmacokinetics, pharmacodynamics, and pharmacometrics approaches, and model-informed drug discovery and development.
- Experience with line management of junior scientists.
What We Offer
GSK is a global biopharma company with a special purpose – to unite science, technology, and talent to get ahead of disease together. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology, and oncology). As a member of our team, you will have the opportunity to work on cutting-edge projects and contribute to the development of innovative treatments for patients worldwide.
