Separation and Purification Scientist

2 months ago

Oxford, Oxfordshire, United Kingdom Exscientia Full time

About Exscientia

We are a pioneering AI-driven precision medicine company committed to discovering, designing, and developing innovative treatments in the most effective and efficient manner possible. Our cutting-edge platform has successfully guided treatment selection and improved patient outcomes in a prospective interventional clinical study, and we have progressed AI-designed small molecules into the clinical setting.

Our Mission

We are dedicated to leveraging our precision medicine platform in oncology and expanding our approach to other therapeutic areas. By pioneering a new approach to medicine creation, we believe the best ideas in science can rapidly become the best medicines for patients.

The Role

We are seeking a highly skilled Separation and Purification Scientist to join our team and contribute to the development and operation of our analytical and purification tools. You will use your expertise in compound analysis and purification to support and develop our fully automated synthesis capability, working closely with our internal synthetic chemistry team.

Key Responsibilities

  • Implement new technology to support automated analytical and purification/separation workflows.
  • Collaborate with our ADME team to support experimental physicochemical parameter measurement, such as Chrom logD and EPSA.
  • Deliver rapid achiral and chiral purification processes for both automated and conventional synthesis workflows.
  • Support automated QC and quantitation workflows using LC-MS and Charged Aerosol Detection.
  • Collaborate with internal and external stakeholders to implement customized software or AI solutions for data manipulation and exploitation.
  • Learn from world-class scientists in various disciplines, using their expertise to inform your work and broaden your knowledge.

Requirements

Essential Skills:

  • Minimum BSc qualification in Chemistry or Pharmaceutical Science, including at least 6 months industrial or academic working experience in Separation Science.
  • Proficiency in analytical LC-MS and/or SFC-MS with a basic understanding of chirality and isomer separation strategies within drug discovery. Proficiency in the operation of mass and/or UV guided purification systems.
  • Proven ability to apply separation science to solve complex problems, and ability to troubleshoot and maintain LC-MS instruments.
  • Innovation mindset with an open-minded attitude to drug discovery technologies and enthusiasm to challenge the status quo.
  • Ability to work in high-performing, cross-functional teams with a collaborative mindset.
  • Strong written and verbal communication skills, as you will liaise with various teams and present your data to colleagues.

Desirable Skills:

  • Experience with batch/plate analysis and automating data processing workflows for QC applications. Experience with alternative detection techniques for compound quantification.
  • Experience with physicochemical parameter measurement using HPLC and SFC methodologies.

What We Offer

  • A dynamic and inclusive work environment with a strong focus on innovation and collaboration.
  • Opportunities for professional growth and development, with access to training and mentorship programs.
  • A competitive salary and benefits package, including a company-wide annual bonus and share awards.
  • A generous holiday allowance and flexible working arrangements to support work-life balance.
  • A comprehensive private health insurance package, dental, and vision benefits for you and your family.
  • Access to mental health support, including therapy and counseling sessions, and an employee assistance program for lifestyle issues.
  • A pension and life cover scheme to support your long-term financial security.
  • A fun and social work environment, with regular team-building activities and social events.

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