Senior Research Scientist

1 month ago


Oxford, Oxfordshire, United Kingdom Oxford Nanopore Technologies Full time

Oxford Nanopore Technologies is a leading biotechnology company headquartered at the Oxford Science Park, with satellite offices and commercial presence in global locations across the US, APAC and Europe. We employ experts from multiple fields including nanopore science, molecular biology, informatics, engineering, electronics, manufacturing, and commercialisation.

The management team, led by CEO Dr Gordon Sanghera, has a track record of delivering disruptive technologies to the market. Our sequencing platform offers real-time analysis in fully scalable formats, capable of analysing native DNA or RNA and sequencing any length of fragment for short to ultra-long read lengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere.

**Job Description**

We are seeking an experienced Development Scientist to join our Biologics Development team. This role will focus on the improvement and performance of biological components within our sample preparation kits and flowcells. The successful candidate will lead projects involving the design, purification, and analysis of key protein components that form the backbone of RNA and DNA sequencing chemistries.

**Responsibilities:**

  • Leading protein engineering projects from conception to conclusion, including strategy, design, testing, and iteration of protein components targeted at improved sequencing performance.
  • Carrying out and improving upon protein expression and purification at lab scale to enable efficient testing of designed protein variants.
  • Detailed characterisation of proteins using classical biochemical techniques and nanopore-based single molecule assays.
  • Robust and thorough data analysis of conducted experiments and accurate reporting to the wider team and division.
  • Guiding junior lab members.

**Requirements:

We are looking for a highly motivated individual with a strong attention to detail, high level of organisation, and effective communication skills. The ideal candidate should have experience in biochemical properties of proteins, recombinant protein expression, and biochemical/biophysical characterisation of purified proteins. A PhD in biochemistry, chemistry, or related field with 1 year or more post-doctoral experience is required, or a BSc/MSc with 6+ years industrial experience and proven track record for project success.

**Salary & Benefits**: We offer an attractive bonus, generous pension contributions, private healthcare, and an excellent starting salary estimated at £60,000 - £80,000 per annum, depending on experience. Based within beautiful landscaped surroundings, all of which make for a wonderful working environment.



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