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Phage Display Research Scientist
2 months ago
CK Group is partnering with Nxera PharmaUK Limited to recruit a Research Scientist/Senior Scientist position in the Protein Binder Discovery team based in Granta Park, Cambridge.
About the CompanyNxera Pharma is a technology-powered biopharma company focused on developing new specialty medicines to improve patient lives in Japan and globally. The company is committed to addressing unmet needs in inflammation diseases, neurology, and immunology.
The RoleWe are seeking an experienced phage display scientist to join the Protein Binders team, part of our Platform Technology division at Nxera Pharma. The successful candidate will use phage display expertise to identify protein binders against therapeutic membrane protein targets, enabling structure determination and drug discovery efforts.
Key Responsibilities- Employ phage display technology to select protein binders against membrane protein targets.
- Screen and validate hits using high-throughput assays, such as ELISA formats, BLI, and cell binding assays.
- Subclone plasmid constructs for expression and protein engineering of VHH frameworks.
- Biophysically evaluate VHH hits.
- Share expertise and insights across the team, project, and department to influence project success.
- PhD or MSc/MRes with equivalent lab experience in a relevant area of biology, with at least 3 years of experience carrying out phage display campaigns.
- Theoretical and practical expertise in phage display technologies and selection techniques.
- Experience working with phage antibody libraries and preferably VHH display.
- Strong molecular biology proficiency.
- Demonstrable expertise in protein-protein interaction screening techniques.
- Dynamic, analytical thinker with good problem-solving skills.
- Strong interpersonal skills and ability to interact effectively with scientists across disciplines.
- Experience measuring affinity using BLI or SPR.
- Experience with affinity maturation.
- Experience with library build (affinity maturation or immunized, naive, or synthetic libraries).
- Experience working with membrane proteins (particularly GPCRs).
- Computational expertise focused on protein binder design.
Please note that applicants must hold entitlement to work in the UK. Please quote job reference 99230 in all correspondence.
