Senior Bioinformatics Lead
11 hours ago
About the role:
The Senior Bioinformatics Lead will play a pivotal part in advancing our ERAP1 inhibitor-driven antigen discovery pipeline. This involves analyzing extensive proprietary datasets, including immunopeptidomic, transcriptomic, and genomic data, to identify ERAP1 inhibitor-dependent targets for MHC class I therapeutics.
Main Responsibilities:
- Develop and maintain high-quality nextflow pipelines for processing large-scale mass spectrometry data.
- Define objectives and perform statistical analysis of data-dependent (DDA) and data-independent (DIA) immunopeptidomics assays.
- Conduct analysis of parallel reaction monitoring (PRM) peptide assays.
- Integrate antigen discovery workflows with transcriptomic and genomic data.
- Leverage external resources and databases to enhance internal workflows and improve target prioritization.
- Stay at the forefront of scientific advances in mass spectrometry-based immunopeptidomics and antigen presentation.
- Lead analytical aspects of projects, including data preparation, analysis, and visualization.
- Provide data-driven insights to inform experimental design.
Additional Responsibilities:
- Demonstrate leadership by adhering to company policies, including data security protocols.
- Complete required GXP/SOP training and comply with relevant SOP requirements.
Requirements:
- PhD in bioinformatics, immunology, computational biology, or related field.
- In-depth knowledge of mass spectrometry-based proteomics data acquisition and processing.
- Strong knowledge of machine learning and multivariate statistical modeling.
- Proficiency in R or Python programming.
- Extensive experience in large-scale bioinformatics analysis of omics data.
- Proficient in Linux OS and shell scripting.
Estimated Salary: $150,000 per year.
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