Senior Bioinformatics Lead

11 hours ago


Oxford, Oxfordshire, United Kingdom Northreach Full time
Advanced Bioinformatics Researcher - Northreach

About the role:

The Senior Bioinformatics Lead will play a pivotal part in advancing our ERAP1 inhibitor-driven antigen discovery pipeline. This involves analyzing extensive proprietary datasets, including immunopeptidomic, transcriptomic, and genomic data, to identify ERAP1 inhibitor-dependent targets for MHC class I therapeutics.

Main Responsibilities:

  • Develop and maintain high-quality nextflow pipelines for processing large-scale mass spectrometry data.
  • Define objectives and perform statistical analysis of data-dependent (DDA) and data-independent (DIA) immunopeptidomics assays.
  • Conduct analysis of parallel reaction monitoring (PRM) peptide assays.
  • Integrate antigen discovery workflows with transcriptomic and genomic data.
  • Leverage external resources and databases to enhance internal workflows and improve target prioritization.
  • Stay at the forefront of scientific advances in mass spectrometry-based immunopeptidomics and antigen presentation.
  • Lead analytical aspects of projects, including data preparation, analysis, and visualization.
  • Provide data-driven insights to inform experimental design.

Additional Responsibilities:

  • Demonstrate leadership by adhering to company policies, including data security protocols.
  • Complete required GXP/SOP training and comply with relevant SOP requirements.

Requirements:

  • PhD in bioinformatics, immunology, computational biology, or related field.
  • In-depth knowledge of mass spectrometry-based proteomics data acquisition and processing.
  • Strong knowledge of machine learning and multivariate statistical modeling.
  • Proficiency in R or Python programming.
  • Extensive experience in large-scale bioinformatics analysis of omics data.
  • Proficient in Linux OS and shell scripting.

Estimated Salary: $150,000 per year.



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