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Senior Scientist Cryo-Electron Microscopy Specialist
2 months ago
CK Group is partnering with Nxera Pharma to recruit a Senior Scientist, Cryo-Electron Microscopy to join their Protein Sciences Group.
About the CompanyNxera Pharma is a technology-driven biopharmaceutical company focused on developing new specialty medicines to improve patient lives globally. Their pipeline addresses major unmet needs in CNS, GI, immunology, metabolic disorders, and rare diseases, leveraging their unique GPCR-targeted structure-based drug discovery platform.
Responsibilities- Support multiple research projects in all steps from grid preparation through to screening and data collection, processing, and model building and interpretation.
- Employ extensive experience in varied data processing workflows, automated pre-processing pipelines, reconstruction of high-resolution maps, model building and validation, and interpretation of structural data.
- Provide technical and strategic input into the cryo-EM team, driving innovation, proposing and implementing developments, and establishing new techniques where appropriate.
- PhD in biochemistry/biophysics with a strong focus on cryo-EM and a minimum of 4 additional years of cryo-EM experience.
- Expert in all microscopy aspects, including microscope preparation, basic maintenance, and troubleshooting, screening, and data acquisition.
- Demonstrable in-depth knowledge of diverse software packages and their application to interpret cryo-EM image data and determine structures.
- Experience in writing and manipulating scripts for handling and processing of cryo-EM data.
- Ability to provide detailed analysis of structural data and contribute to hypotheses for structure-based design.
- Excellent organizational and time-management skills, as well as the ability to work to deadlines.
- Ability to offer technical guidance and training to other team members.
- Strong interpersonal skills and ability to interact effectively with scientists across disciplines in a program-centric approach to generate timely and informative structural data for project teams.
- Ability to communicate effectively internally and with external partners and collaborators.
- Experience working within a collaborative, multi-disciplinary environment, preferably in a pharmaceutical/biotech setting, with a demonstrable track record of scientific achievements and contributions.
- Experience of using EM for structure determination of membrane proteins would be a distinct advantage.
- State-of-the-art R&D centre located in the heart of the Cambridge science cluster.
- Competitive compensation package including discretionary cash bonuses.
- Eligible for grants of Restricted Stock Units.
- 25 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year.
- Employer contribution to pension.
- Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement.
- Health and wellbeing benefits including a subsidised individual gym membership.
- Income protection to cover long-term absences due to ill health.
- Group Death in Service equal to 4x basic annual salary.
