Senior Postdoctoral Researcher

4 weeks ago

Dundee, Dundee City, United Kingdom University of Dundee Full time
Job Title: Senior Postdoctoral Researcher

We are seeking a highly motivated and experienced Senior Postdoctoral Researcher to join our team at the University of Dundee's MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU). The successful candidate will be part of a new academic-industrial global initiative supported by the Michael J Fox Foundation for Parkinson's Research.

The project aims to explore and validate new approaches to target LRRK2, perform systematic mechanistic, structural and safety analyses to benchmark new LRRK2 modifiers, and identify clinically relevant biomarkers for LRRK2-driven Parkinson's disease. The successful applicant will have previous knowledge and expertise in one or more of the following areas:

  1. Mechanistic cell biology employing a multidisciplinary approach including molecular, biochemical, physiological, mass spectrometry, pharmacological and genetic methodologies.
  2. Screening and characterisation of compounds in in vitro and in vivo assays.
  3. Protein purification.
  4. Structural biology.
  5. Computational and AI modelling for hit discovery and optimisation.
  6. Biophysical assays to investigate protein/protein interactions and for compound screening.
  7. Quantitative mass spectrometry analysis (proteomic, lipidomic, metabolomic, post translational modifications), preferably in clinical samples.
  8. Bioinformatic methodologies and analysis of large datasets including mass spectrometry data.

The successful candidate will be expected to independently design, develop and implement a range of strategies and approaches required across different projects and to supervise and guide other research team members in the delivery of their project. In addition, the successful candidate will be responsible for the day-to-day project leadership with minimal input from the Principal Investigators, and data and resource management.

Your Key Responsibilities:
    • To lead a research project in the relevant discipline area using the appropriate methods and/or techniques.
    • To take responsibility for project development and implementation, including experimental design and identification and development of a broad range of techniques necessary to achieve the research objectives.
    • To independently design, develop and implement a range of strategies and approaches required across different projects.
    • Be responsible for the day-to-day project leadership with minimal input from the Principal Investigators, and data and resource management.
    • To provide supervision, guidance and support to other staff and students within the research team.
    • To collaborate with research colleagues and support staff internally as appropriate to the research.
    • To support the production of research reports and/or publications as required by the funding body or for dissemination to the wider academic community.
    • To undertake any other duties relevant to the programme of research as required.
    • To take on wider responsibilities within the team as required.
Requirements:
    • Applicants must have a PhD in a relevant discipline with strong academic track record and at least one first-authored publication either submitted to a preprint server or published in an internationally recognised peer-reviewed journal.
    • Significant relevant experience in academic or industrial environment along with demonstrated track record of project leadership roles.
    • Strong knowledge and interest in understanding pathways that are linked to neurodegeneration and Parkinson's disease and an appreciation of how research in this area can be exploited to accelerate drug discovery.
    • Demonstrated experience in the design, development and implementation of a range of strategies and approaches required for the successful delivery of a research project.
    • Experience in supervision of junior members of a research team.
    • Significant hands-on expertise in one or more of the following: biochemistry, mass spectrometry, cell biology, molecular biology, structural biology, signal transduction, data analysis and bioinformatic analysis.
    • Hands-on experience in experimental techniques and data analysis that are relevant to the role.
    • Experience in independent research projects including interdisciplinary work.
    • Experience in multi-institutional and/or industry collaborations is highly desirable.
    • Ability to work in a team in a highly collaborative manner, embracing the principles of Open Science.
    • Excellent interpersonal and organisational skills.
    • Excellent knowledge of the English language is essential.

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