Senior Biophysical Scientist

3 weeks ago

Cambridge, Cambridgeshire, United Kingdom Nxera Pharma Full time

About the Role:

We are seeking a highly motivated and experienced biophysical scientist to join our Protein Sciences group at our research facility in Cambridge, UK. The successful candidate will be responsible for delivering quantitative biophysical analysis on protein-ligand binding using surface plasmon resonance (SPR). This will include affinity and kinetic data to inform chemical design and mechanistic understanding.

Key Responsibilities:

  • Deliver high-quality biophysical analysis on protein-ligand binding using SPR.
  • Generate high-fidelity and reproducible data and insights into the molecular mechanism of lead compounds and drug candidates.
  • Conduct fragment and other compound screens, validate and characterise hits from these screens to inform design.
  • Identify and drive improvements and innovations in SPR-related techniques to expand the scope of biophysical approaches currently employed at Nxera Pharma.
  • Collaborate with various Nxera Pharma scientists on research projects that successfully advance membrane protein targets through the Nxera Pharma structure-based drug design pipeline.
  • Prepare and effectively present results (written and oral) to project teams.

Requirements:

  • Masters Degree and/or PhD in Biochemistry/Biophysics or a related discipline with proven and demonstrable SPR experience in a drug discovery environment.
  • Expertise in challenging and innovative characterisation of molecular interactions and mechanistic insights using SPR.
  • Experience in other biochemical and biophysical methods such as nDSF, NMR or quantitative mass spectrometry would be considered an advantage.
  • Previous experience with membrane proteins would be desirable.
  • Strong interpersonal skills and the ability to interact effectively with collaborators from various disciplines.

About Us:

Nxera Pharma is a technology-powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs globally. We employ over 350 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and are listed on the Tokyo Stock Exchange (ticker: 4565).

Our Mission:

To accelerate the development of life-changing medicines, by investing in science and technology.

Our Vision:

To lead the next era of medicine. From Japan, for Japan, and the world.

How to Apply:

Applications should include a CV and covering letter, providing a short description of the background of your interest in the role and sent to Sav Bassi at sav.bassi@ext.nxera.life.

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