Senior Scientist

3 days ago

Manchester, United Kingdom SENIOR SPIRIT OF ROSELLE PARK Full time
About the Role

We are seeking a highly skilled Senior Scientist to join our team at SENIOR SPIRIT OF ROSELLE PARK, a leading precision medicine company. As a Senior Scientist, you will play a key role in the development of clinically applicable targeted assays using LC-MS/MS technology.

Key Responsibilities
  • Assay Development: Develop targeted LC-MS methods on a triple quadrupole mass spectrometer to accurately and robustly quantify phosphopeptide biomarkers arising from our R&D work.
  • Quality Control and Normalisation: Devise strategies for normalisation and quality control to ensure tests are accurate, reproducible, and reliable, and to ensure we adhere to relevant quality standards.
  • Collaboration and Documentation: Work with the product development team and quality manager to ensure appropriate systems, monitoring, and documentation are in place during development of a test which can ultimately be relied upon to aid patient treatment decision making.
  • Regulatory Submissions: Author and/or contribute to regulatory submissions, technical protocols, and reports.
General LC-MS/MS Operation and Maintenance
  • System Maintenance: Work with the Mass Spectrometry Technical Lead to ensure that LC-MS/MS systems are regularly maintained and calibrated, that all buffers are properly prepared and regularly replaced, and to ensure that the proper Quality Control samples are run, and robust checks are in place.
  • Documentation and Reporting: Outputs of all maintenance, calibrations, QC work are to be documented for reporting purposes.
  • Process Improvement: Make process improvements and project efficiencies wherever possible and contribute freely to the team environment in a manner conducive to the success of company goals.
Your Background
  • Education: PhD (or equivalent experience) in a relevant or STEM-based subject.
  • Experience: ≥2 years of hands-on experience running/operating high-end LC-MS/MS systems, including hands-on experience calibrating the MS systems, basic maintenance of LC-MS/MS, renewing buffers, running QCs, interpreting data, and reporting QC outputs.
  • Specific Experience: Specific experience running triple quadrupole mass spectrometers and developing targeted methods.
  • Expertise: Expertise developing clinical assays utilising LC-MS/MS proteomic technologies.
  • Software Skills: Experienced interrogating LC-MS/MS raw data using vendor software (e.g., Thermo's Xcalibur/Freestyle/Chromeleon, or SciexOS).
  • Soft Skills: Excellent organisational skills and time management skills, a high degree of personal motivation, and a willingness to learn new skills, take on challenges, and undertake relevant training.
Desirable Qualifications
  • Quality Management Systems: Experience with quality management systems and documentation.
  • Mass Spec Instrumentation: Experience in developing and validating mass spec instrumentation and methods.
  • Regulated Environment: Experience working to ISO 15189, CLIA, or working in a similar regulated environment.
  • Medical Device Design: Knowledge of medical device design control processes.
  • Proteomic Workflows: Experienced in preparing samples using proteomic workflows for LC-MS/MS analysis.
  • Biological Systems: Knowledge and understanding of fundamental principles of biochemical and molecular biological systems.
  • Biomarker Discovery: Expertise in the utilisation of LC-MS/MS proteomic technologies for the identification and validation of clinical biomarkers.

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