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Protein Binder Discovery Specialist

2 months ago

Cambridge, Cambridgeshire, United Kingdom CK Group Full time
About the Role

CK Group is partnering with Nxera PharmaUK Limited to recruit a Research Scientist/Senior Scientist position in the Protein Binder Discovery team. The successful candidate will join a dynamic team focused on developing innovative protein binders for therapeutic applications.

Key Responsibilities
  • Employ phage display technology to select protein binders against membrane protein targets.
  • Screen and validate hits using high-throughput assays, such as ELISA formats, BLI, and cell binding assays.
  • Subclone plasmid constructs for expression and protein engineering of VHH frameworks.
  • Biophysically evaluate VHH hits.
  • Share expertise and insights across the team, project, and department to influence project success.
Requirements
  • PhD or MSc/MRes with equivalent lab experience in a relevant area of biology, with at least 3 years of experience carrying out phage display campaigns.
  • Theoretical and practical expertise in phage display technologies and selection techniques.
  • Experience working with phage antibody libraries and preferably VHH display.
  • Strong molecular biology proficiency.
  • Demonstrable expertise in protein-protein interaction screening techniques.
  • Dynamic, analytical thinker with good problem-solving skills.
  • Strong interpersonal skills and ability to interact effectively with scientists across disciplines.
Desirable Skills
  • Experience measuring affinity using BLI or SPR.
  • Experience with affinity maturation.
  • Experience with library build (affinity maturation or immunized, naïve, or synthetic libraries).
  • Experience working with membrane proteins (particularly GPCRs).
  • Computational expertise focused on protein binder design.