Senior Bioinformatics Specialist

4 days ago

Oxford, Oxfordshire, United Kingdom Oxford Nanopore Technologies Full time
Job Summary

We are seeking a highly skilled Senior Bioinformatics Specialist to join our team at Oxford Nanopore Technologies. As a key member of our human genetics applications team, you will play a pivotal role in evaluating the performance of internal and community analysis tools on Nanopore Data, working closely with internal and external partners to develop, improve, and showcase important tools and applications.

Key Responsibilities
  • Evaluate, plan, prioritize, and conduct experiments and data analysis with a focus on extracting meaningful insights relevant to the application of Nanopore's sequencing platform to human translational genetics.
  • Prototype innovative bioinformatics analysis and pipelines, defining best practices specifically tailored for human genetics, as well as performance testing and improving of existing pipelines according to requirements agreed upon with internal stakeholders.
  • Communicate results, recommendations, and problems to internal stakeholders, including commercial teams and R&D.
  • Develop and maintain relationships with community leaders in human genetics applications and tool development, working with these scientists to understand requirements and gaps in the field, and to remedy them when possible.
  • Interface with various teams, including customer workflows and commercial teams like marketing and product management, to integrate bioinformatics solutions and analysis into broader organizational goals.
  • Work closely with internal stakeholders to provide technical assessment, development, and support to key accounts in order to promote broader adoption of human genetics translational applications using nanopore devices.
Requirements
  • Relevant PhD and post-doc (or equivalent industry experience) plus 5 years of biotechnology industry experience with a human genetics focus.
  • Experience of developing analysis tools and/or pipelines for long-read sequencing data in the field of human genetics.
  • Expertise in bioinformatics and statistics, with in-depth knowledge of the range and limitations of existing bioinformatics tools in the context of next-generation sequencing.
  • Experience in at least one human genetics application of next-generation sequencing.
  • Track record of successfully performing appropriate bioinformatics sequence analyses for a range of different kinds of human genetics projects.
  • Practical experience of handling and analyzing large data sets and working closely with lab scientists to continually refine the experimental and analytical approaches.
  • Ability to communicate technical findings to non-technical internal and external stakeholders.
  • Versatility and the ability to work on multiple projects simultaneously.
  • Experience with scripting languages, e.g., Python, R, etc.
  • Up-to-date knowledge of the latest literature about NGS and analysis of human genetics data.

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