Scientific Innovation Leader for Protein Chemistry and Analytics

3 hours ago

Slough, Slough, United Kingdom Lonza Full time
Lead Scientific Innovation in Protein Chemistry

We are seeking an experienced Principal Scientist to join our Protein Chemistry group within the Protein and Process Analytics (P&PA) R&D team at Lonza, a global leader in life sciences.

About the Role

The successful candidate will be responsible for delivering high-value technical innovation through analytical projects and collaborative project teams. With extensive experience in MS characterisation of proteins, you will oversee the scientific activities of the team, including study design, laboratory work, scientific review, coaching, project leadership & management, professional mentoring, technology scouting, and driving implementation of new technologies within the Lonza network.

Main Responsibilities
  • Provide oversight and execute scientific activities with elements of study design and implementation, laboratory work, scientific review, coaching of junior scientists, project leadership & management, professional mentoring, technology scouting.
  • Evaluate and develop innovative Protein characterisation methods and workflows to support biologics process development.
  • Perform technology scouting and drive implementation of new technologies and software within the Lonza network.
  • Provide scientific leadership and direction within the team and lead strong collaboration efforts across the Bio R&D department to maximize synergies and impact.
  • Engage in external collaborations and disseminate results through publications and participation in high-profile conferences and workshops.
Requirements and Qualifications

To be successful in this role, you will need:

  • A PhD Degree in Life Sciences/Science or equivalent; preferred area of study: Biochemistry/Biomanufacturing/Biotechnology.
  • Extensive industry experience (5+ years) in an analytical laboratory focused on MS method development and Protein Characterisation by Mass Spectrometry approaches.
  • Detailed knowledge and practical application of liquid chromatography (SEC, IEX, HILIC, HIC, RP, affinity), mass spectrometry (LC-MS, LC-MS/MS), other separation methods (icIEF, CE-SDS) for protein analysis, and QbD for method development.
  • Thorough understanding of state-of-the-art technologies and their applications for protein analysis, including charge and size variant analysis, titer measurement, glycosylation analysis, product-related impurities, and determination of post-translational modifications (PTMs).
  • Experience with various protein formats, e.g., mAbs, bispecific Abs, fusion proteins, and complex glycoproteins.
  • Research-focused, with a keen interest in innovation within the biologics area.
  • A good general background in established analytical methods within the industry, including the strengths and weaknesses of various approaches.
  • Documented history of high-quality publications/patent filings in the field of Protein Chemistry.
  • Excellent communication and interpersonal skills, with the ability to directly influence stakeholders in a scientific capacity and deliver technical projects within a matrix organization.
  • Intellect for scoping and design of complex projects.
  • High level of empathy and desire to see others succeed.
  • Proven ability to deliver innovative solutions to scientific challenges, within specific timelines and defined success criteria.
  • Resilient to setbacks and able to motivate self and others under challenging conditions.
  • Ability to take calculated risks.
Salary and Benefits

The estimated salary for this position is $120,000 - $180,000 per year, depending on experience and qualifications. We offer a comprehensive benefits package, including health insurance, retirement savings plan, and paid time off.

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