Senior Research Scientist, In Vivo Pharmacology and Tumor Biology

7 days ago


Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
About the Role

Bicycle Therapeutics is seeking a highly skilled and experienced Research Scientist to join our team in In Vivo Pharmacology and Tumor Biology. As a key member of our research team, you will play a critical role in supporting the preclinical research and discovery efforts for our expanding portfolio of Bicycle-based therapeutics.

Key Responsibilities
  • Design and Interpret In Vivo Pharmacology Studies: Develop and execute in vivo pharmacology studies to evaluate the activities of Bicycle Toxin Conjugates (BTC), Bicycle Radio Conjugates (BRCTM), and other compounds in our pipeline, including their mechanism of action and PK/PD/efficacy relationships.
  • Manage In Vivo Pharmacology Research: Oversee in vivo pharmacology research through a network of Contract Research Organizations (CROs) and academic collaborations, ensuring timely and high-quality results.
  • Collaborate with Cross-Functional Disciplines: Effectively collaborate with biology, DMPK, translational sciences, and toxicology teams to drive decisions and advance our research pipeline.
  • Document and Communicate Results: Effectively document and communicate research results company-wide, presenting findings in diverse settings, including project team meetings and internal scientific forums.
  • Identify and Validate Pharmacodynamic Biomarkers: Identify and validate pharmacodynamic biomarkers to support preclinical and clinical development, ensuring the successful advancement of our pipeline.
  • Lead In Vivo Pharmacology Sample Management: Oversee the management of in vivo pharmacology samples, ensuring accurate and efficient data collection and analysis.
  • Author Publications and Presentations: Author publications in peer-reviewed journals and represent Bicycle Therapeutics at conferences, presenting scientific findings in poster or oral formats.
Qualifications
  • Education and Experience: Educated in a biological sciences field with extensive industrial experience, preferably in in vivo oncology models.
  • Hands-on Experience: Hands-on experience using multiple types of in vivo oncology models, with a strong background in cancer biology.
  • Preferred Qualifications: Experience working with toxin- or radionuclide-conjugates, in vivo model development and validation, pre-clinical in vivo SPECT or PET nuclear medicine imaging techniques, and managing external work/collaborations.
What We Offer
  • State-of-the-Art Campus Environment: Work in a state-of-the-art campus environment with on-campus amenities and a collaborative team culture.
  • Competitive Rewards: Enjoy a competitive reward package, including annual company bonus, employee recognition schemes, and a comprehensive benefits package.
  • Flexible Working Environment: Work in a flexible and dynamic environment that supports work-life balance and career growth.

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