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Senior Bioinformatics Lead

2 months ago

London, Greater London, United Kingdom Autolus Limited Full time
Job Summary

We are seeking a highly skilled and motivated Bioinformatician to lead the development and delivery of integrated analyses, including but not limited to Whole Exome Sequencing (WES), RNA sequencing (RNAseq), clinico-demographic, and biomarker data from patients treated with CAR-T therapy from Autolus' pipeline.

Key Responsibilities
  • Data Integration and Management:
    • Lead the integration of WES, RNAseq, clinico-demographic, and biomarker data from clinical trials and research studies.
    • Develop and implement pipelines and workflows for data processing and integration, ensuring high-quality data management and consistency.
    • Maintain and update databases and data management tools, ensuring data accuracy, security, and compliance with regulatory standards.
  • Bioinformatics Analysis:
    • Perform comprehensive bioinformatics analyses, including variant calling, copy number change, differential expression analysis, pathway analysis, and biomarker discovery in the context of the clinical environment.
    • Utilize statistical and computational tools to interpret multi-omics data and generate meaningful medical and biological insights.
    • Develop and validate predictive models for patient outcomes to CAR-T therapy based on integrated data.
  • Collaboration and Communication:
    • Work closely with cross-functional teams, including clinical, R&D and biostatistics groups, to support data needs and project objectives.
    • Provide bioinformatics expertise and guidance to collaborators, ensuring effective data usage and interpretation.
    • Collaborate with external partners and vendors as necessary to enhance data integration and analysis capabilities.
  • Scientific Publications:
    • Lead the preparation of scientific manuscripts and reports based on integrated data analyses.
    • Contribute to the writing, editing, and submission of scientific publications in high-impact journals.
    • Present findings at scientific conferences, meetings, and internal forums to communicate research outcomes and advance the understanding of CAR-T therapy.
  • Tool Development and Innovation:
    • Develop custom scripts, tools, and software applications to support data integration, analysis, and visualization.
    • Stay abreast of the latest bioinformatics methodologies, technologies, and industry trends to drive innovation and improve data integration processes.
  • Quality Control and Documentation:
    • Ensure quality control of bioinformatics analyses and results, adhering to best practices and standard operating procedures.
    • Document all processes, analyses, and results thoroughly, providing clear and detailed records for reproducibility and regulatory compliance.