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Senior Scientist, Crystallisation Development Expert
2 months ago
We are seeking a highly skilled and experienced Senior Scientist to join our team at Pharmaron. As a technical expert in Crystallisation Development, you will have the opportunity to leverage your advanced knowledge in analytical techniques, support materials science, analytical chemistry, formulation development, chemical engineering, and process chemistry projects.
Key Responsibilities- Support crystallisation and isolation process development through laboratory experiments and materials characterisation assessment of starting materials, intermediates, and APIs.
- Monitor reaction pathways and kinetics using appropriate Process Analytical Technology (PAT).
- Conduct analysis of product samples for key physical properties, including XRPD, optical microscopy, PSD, and other relevant techniques.
- Assess polymorph landscape for final APIs and define thermodynamically stable form.
- Assess solubility in various media using appropriate methods.
- Support clients in defining final salt and polymorphic form based on a full materials characterisation assessment.
- Support preformulation assessment of final phases.
- Work within project teams to meet tight deadlines.
- Able to step in and learn new techniques to support projects.
- Able to solve complex scientific problems.
- Able to work effectively in a Good Manufacturing Practice (GMP) laboratory.
- Present and communicate clearly and effectively with clients.
- PhD in chemistry or a relevant related subject with a technical focus on crystallisation for purity upgrade or particle engineering or PAT (additional industrial or academic experience preferred), or an MSC in chemistry with several years of relevant industrial experience in crystallisation development or PAT.
- Knowledge of crystallisation methodologies relevant to drug substances.
- Familiarity with in-situ process analytical technologies for crystallisation process development (desired).
- Knowledge of data analytics and data visualisation tools.
- Knowledge of Design of Experiments (DoE) and related software (desired).
- Significant expertise in troubleshooting and developing materials characterisation methods, including XRPD, DSC, TGA, DVS, microscopy, and PSD.
- Experience using the following equipment would also be desired, although not essential: Technobis Crystal 16, Crystalline or Crystal breeder, Mettler React IR, FBRM, Easymax, other Spectroscopic PAT such as NIR or Raman.
- Strong scientific record of accomplishment.
Pharmaron is a cutting-edge company that tackles the toughest scientific challenges for the world's leading pharmaceutical companies. We operate with ethics, integrity, and professionalism, and we work as a team to empower our employees to reach their full potential. Our Hoddesdon campus in Hertfordshire is a hub of innovation and excellence, with over 5,000m2 of premier R&D space, including state-of-the-art GMP facilities for API, formulation, and process chemistry.
What We Offer- A competitive salary and a progressive and comprehensive suite of employee benefits.
- A state-of-the-art working environment in our modern Hoddesdon site.
- The opportunity for growth and development, with support for funding relevant training and development programmes.
