Senior Scientist, Crystallisation Development Expert

2 weeks ago

Hoddesdon, Hertfordshire, United Kingdom Pharmaron Full time
Unlock Your Expertise in Crystallisation

As a seasoned technical expert in Crystallisation, you will have the opportunity to leverage your advanced knowledge in analytical techniques to drive innovation in materials science, analytical chemistry, formulation development, chemical engineering, and process chemistry projects. You will collaborate effectively with Process Chemistry, Product Development, and Analytical Chemistry colleagues to develop and characterise Starting Materials, Intermediates, APIs, and formulations.

About the Role

Key responsibilities include:
  • Supporting crystallisation and isolation process development through laboratory experiments and materials characterisation assessment of starting materials, intermediates, and APIs.
  • Monitoring reaction pathways and kinetics using appropriate Process Analytical Technology (PAT).
  • Conducting analysis of product samples for key physical properties, including XRPD, optical microscopy, PSD, and other relevant techniques.
  • Assessing polymorph landscapes for final APIs and defining thermodynamically stable forms.
  • Assessing solubility in various media using appropriate methods.
  • Supporting clients in defining final salt and polymorphic forms based on a full materials characterisation assessment.
  • Supporting preformulation assessments of final phases.
  • Working within project teams to meet tight deadlines.
  • Able to step in and learn new techniques to support projects.
  • Able to solve complex scientific problems.
  • Able to work effectively in a GMP laboratory.
  • Presenting and communicating clearly and effectively with clients.

Requirements

The ideal candidate will possess a PhD in chemistry or a related subject with a technical focus on crystallisation for purity upgrade or particle engineering or PAT, or an MSC in chemistry with several years of relevant industrial experience in crystallisation development or PAT. Key skills include knowledge of crystallisation methodologies relevant to drug substances, familiarity with in-situ process analytical technologies for crystallisation process development, and knowledge of data analytics and data visualisation tools. Significant expertise in troubleshooting and developing materials characterisation methods, including XRPD, DSC, TGA, DVS, microscopy, and PSD, is also required. Experience with equipment such as the Technobis Crystal 16, Crystalline, or Crystal breeder is desirable.

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