Senior Chemistry Manager

3 days ago

Cambridge, Cambridgeshire, United Kingdom Sphere Fluidics Limited Full time
Job Description

Job Title: Senior Chemistry Manager

Functional Area: Research and Development

Salary Range: £55,000 - £65,000 per annum

Reports to: Director of Science

Location: Cambridge, UK (hybrid working available)

Job Type: Full Time / Permanent

About Sphere Fluidics Limited:

Sphere Fluidics Limited is a leading company in single cell analysis and isolation technologies. Our innovative platforms are built on scientific and engineering expertise spanning over a decade. Originally spun out from the University of Cambridge, we specialize in helping researchers find their most critical cells. Leveraging our picodroplet microfluidic technology, we offer high-throughput solutions for single cell isolation and analysis across various applications, including biologics discovery, cell engineering, and synthetic biology.

Job Summary:

The Senior Chemistry Manager will lead a team of chemists and collaborate with the biology team to develop novel reagents and applications related to our microfluidic droplet-based single cell analysis platforms. The successful candidate will drive business growth by extending the application, improving the performance, and reducing the cost of our reagent systems.

Main Responsibilities:

  • Develop novel high-performance reagent systems for droplet-based microfluidic single-cell analysis, including oil and aqueous phases, emulsifiers, stabilisers, surfactants, shell structures, de-emulsifiers, hydrogels, and surface coatings for microfluidic chips.
  • Develop scalable, cost-effective, synthesis routes and processes to manufacture reagents and support their transfer to manufacture, either in-house or with third parties.
  • Establish robust reagent material specifications and develop the necessary assessment techniques to support quality during manufacture.
  • Support operational efforts to reduce manufacturing cost, including assessment of alternative materials and development of more efficient manufacturing processes.
  • Work collaboratively with the biology team to design novel and alternative solutions for application and assay development, such as protein labelling, enzymatic, and covalent conjugation.
  • Work closely with biologists and other scientists to integrate chemical solutions into biological assays.
  • Utilize advanced chemical techniques and methodologies to support the development of reagents and components for assay kits.
  • Line management of the chemistry team, driving recruitment and capability growth to align with business needs.
  • Plan and execute design and development projects to create new reagents and reagent systems.
  • Assist in developing requirements and specifications for new platforms.
  • Act as an internal consultant, champion, and expert in chemistry for the company, particularly for cross-discipline R+D projects.
  • Perform due diligence and assessment on competitive science and IP in the field of droplet chemistry and ensure the company's technical know-how is up to date by regular review of the scientific literature and conference attendance.
  • Develop and refine internal processes to drive efficient project execution and maximize effectiveness of our chemistry team within our ISO9001 Quality Management System.
  • Oversee our in-house chemistry development lab and ensure equipment and processes are fit-for-purpose.
  • Oversee safety, health, and environmental activities for all chemistry work and ensure compliance with appropriate regulations and safety procedures.
  • Monitor proposed future regulations for environment, health, and safety that may affect our business in all markets and ensure the Senior Leadership Team is aware of potential impacts.

Requirements:

  • PhD degree in chemistry in a technical area directly relevant to droplet microfluidics.
  • Up-to-date technical expertise in droplet chemistry, familiar with the challenges presented in developing robust, highly stable, biocompatible emulsions.
  • Expertise in chemical synthesis, purification, and characterization techniques.
  • Strong knowledge of assay development, including fluorescence-based assays.
  • Proficiency in analytical techniques such as HPLC, MS, NMR, and spectroscopy.
  • Experience of developing reagents in a commercial context for the life-sciences industry and transferring them to manufacture, particularly the challenges of defining quality and meeting cost targets.
  • Good knowledge of measurement and characterization techniques as applied to droplet system reagents and structures.
  • Able to think creatively and propose novel ideas for new reagents and chemical structures, and the associated synthesis techniques.
  • Experience of leading reagent design and development projects.
  • Familiar with product development processes, particularly requirements capture, project planning, and delivery and verification/validation methods.
  • Good data analysis and problem-solving skills, able to identify root causes and implement robust action plans.
  • Experience in growing and developing high-performance technical teams.
  • Strong organizational skills, able to set standards and encourage others to succeed.
  • Familiar with environment, health, and safety legislation and processes, particularly UK COSHH.
  • Team-orientation toward collaboration and mutual success.

Benefits:

  • 25 days holiday plus bank holidays.
  • Employee Share Options (EMI Scheme).
  • Company pension scheme with Aviva (employer contributes 8%).
  • 4x Life Insurance & Critical Illness Cover.
  • Private Medical Insurance with Vitality.
  • Health Cash Plan.
  • Group Income Protection.
  • Employee Assistance Program.
  • Cycle to Work scheme.
  • Learning & Development opportunities for career growth.
  • Long Service Bonus – up to 5 extra days holiday.
  • Recruitment referral scheme (£1,000).
  • Flexible working hours to support work-life balance.

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