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Senior Scientist Phage Display Specialist
2 months ago
Nxera Pharma is seeking a highly skilled Research Scientist/Senior Scientist to join their Protein Binder Discovery team in Granta Park, Cambridge. The successful candidate will utilize phage display expertise to identify protein binders against therapeutic membrane protein targets, contributing to the development of life-changing medicines.
About the Role
The ideal candidate will have a strong background in phage display technologies and selection techniques, with experience working with phage antibody libraries and VHH display. They will be responsible for employing phage display technology to select protein binders, screening and validating hits using high-throughput assays, and sharing their expertise across the team.
Key Responsibilities
- Employ phage display technology to select protein binders against membrane protein targets
- Screen and validate hits using high-throughput assays, such as ELISA formats, BLI, and cell binding assays
- Subclone plasmid constructs for expression and protein engineering of VHH frameworks
- Biophysically evaluate VHH hits
- Share expertise and insights across the team to influence project success
Requirements
- PhD (or MSc/MRes with equivalent lab experience) in a relevant area of biology with at least 3 years of experience carrying out phage display campaigns
- Theoretical and practical expertise in phage display technologies and selection techniques
- Experience working with phage antibody libraries and preferably VHH display
- Strong molecular biology proficiency
- Demonstrable expertise in protein-protein interaction screening techniques
- Dynamic, analytical thinker with good problem-solving skills
- Effective interpersonal skills to interact with scientists across disciplines
Desirable Skills
- Experience measuring affinity using BLI or SPR
- Experience with affinity maturation
- Experience with library build (affinity maturation or immunized, naive, or synthetic libraries)
- Experience working with membrane proteins (particularly GPCRs)
- Computational expertise focused on protein binder design
How to Apply
Please quote job reference 99230 in all correspondence.
