Senior Scientist

1 month ago

Edinburgh, Edinburgh, United Kingdom RoslinCT Full time
RoslinCT is a global Contract Development and Manufacturing Organisation (CDMO) specializing in Advanced Cell and Gene Therapies. Our company was founded in 2006, building on the groundbreaking cloning technology of Dolly the Sheep. We are one of the first to produce clinical-grade human pluripotent stem cells and have developed the first CRISPR-edited cell therapy product for a major inherited disorder, taking it from early development to commercialization.

We are seeking an Associate Principal Development Scientist - Cell Processing and Gene Modification Lead to join our team. This senior position has a significant hands-on component and is responsible for providing leadership to the Process Development Cell Processing and Gene Modification Team within Process Development.

Key Responsibilities:
• Provide vision and strategic scientific leadership in a hands-on setting, sharing cell culture work and providing practical technical SME support to others in the Process Development Cell Processing and Gene Modification team.
• Ensure strategic alignment with the Chief Scientific and Technology Officer, Innovation, and QC departments.
• Develop cell product manufacturing unit operations, including apheresis processing, target cell selection, cell differentiation or activation, cell engineering, delivery methods (e.g., electroporation), cell expansion, harvest, formulation, and cryopreservation.
• Collaborate with Business Development to scope/cost new projects and win new business.
• Develop plans for method development, transfer, and qualification.
• Stay abreast of global Cell and Gene Therapy/Sterile Manufacturing regulatory guidelines and trends.
• Formulate realistic, tangible plans and solutions aligned with multi-project deliverables.
• Directly manage Cell Processing and Gene Modification Scientists, including recruitment, training, and performance management.
• Ensure quality, compliance, and good laboratory practices (non-GMP and GMP).
• Manage change, including work patterns, project scopes, and ad hoc events.
• Review technical reports, investigations, complex change controls, deviations, and risk assessments.
• Promote high standards of good laboratory practices and technical report writing.
• Own and influence policies and procedures relevant to your area of responsibilities.
• Maintain professional communication with colleagues, client representatives, and the wider scientific community.

Requirements:
• Hands-on experience in Cell and Gene Therapy cell process development and current technologies.
• Familiarity with cell product manufacturing unit operations, including apheresis processing, target cell selection, cell differentiation or activation, cell engineering, delivery methods (e.g., electroporation), cell expansion, harvest, formulation, and cryopreservation.
• Exceptional organisational, time management, and computer skills (Microsoft Word and Excel).
• A Life Sciences Degree, Master, or PhD in a related subject, with previous experience in a CDMO manufacturing-focused environment.

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