Principal Scientist, Biologics R&D

2 months ago

Slough, Slough, United Kingdom Lonza Full time
About the Role

We are seeking a highly motivated and experienced Principal Scientist to join our Protein Chemistry group within the Protein and Process Analytics (P&PA) R&D team at Lonza. As a key member of our team, you will be responsible for delivering high-value technical innovation through analytical projects and collaborative project teams.

Key Responsibilities
  • Provide scientific leadership and direction within the team, overseeing and executing scientific activities, including study design, laboratory work, scientific review, coaching of junior scientists, project leadership & management, professional mentoring, technology scouting, and driving implementation of new technologies within the Lonza network.
  • Evaluate and develop innovative protein characterization methods and workflows to support biologics process development.
  • Perform technology scouting and drive implementation of new technologies and software within the Lonza network.
  • Provide scientific leadership and direction within the team, leading strong collaboration efforts across the Bio R&D department to maximize synergies and impact.
  • Engage in external collaborations and disseminate results through publications and participation in high-profile conferences and workshops.
  • Act as a protein characterization (MS) SME in multiple collaborative projects, guiding analytical discussions, translating data into the project context, and supporting project decision-making.
Requirements
  • PhD Degree in Life Sciences/Science or equivalent; preferred area of study: Biochemistry/Biomanufacturing/Biotechnology.
  • Extensive industry experience (5+ years) in an analytical laboratory focused on MS method development and protein characterization by Mass Spectrometry approaches.
  • Detailed knowledge and practical application of liquid chromatography (SEC, IEX, HILIC, HIC, RP, affinity), mass spectrometry (LC-MS, LC-MS/MS), other separation methods (icIEF, CE-SDS) for protein analysis, and QbD for method development.
  • Thorough understanding of state-of-the-art technologies and their applications for protein analysis, including charge and size variant analysis, titer measurement, glycosylation analysis, product-related impurities, and determination of post-translational modifications (PTMs).
  • Experience with a variety of protein formats, e.g., mAbs, bispecific Abs, fusion proteins, and complex glycoproteins.
  • Research-focused, with a keen interest in innovation within the biologics area.
  • Good general background in established analytical methods within the industry, including the strengths and weaknesses of various approaches.
  • Documented history of high-quality publications/patent filings in the field of protein chemistry.
  • Excellent communication and interpersonal skills, with the ability to directly influence stakeholders in a scientific capacity and deliver technical projects within a matrix organization.
  • Intellect for scoping and design of complex projects.
  • High level of empathy and desire to see others succeed.
  • Proven ability to deliver innovative solutions to scientific challenges, within specific timelines and defined success criteria.
  • Resilient to setbacks and able to motivate self and others under challenging conditions.
  • Ability to take calculated risks.

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