Mammalian Cell Culture Specialist
1 month ago
Rjevity is a leading life science company that delivers science-driven research solutions advancing the understanding of the genetic basis of disease and the delivery of better healthcare outcomes for patients. We act as a discovery partner for leading pharma and biotech companies worldwide, providing research services and tools to support the development of personalized medicines.
Job SummaryWe have an exciting opportunity for a Scientist 2 to join our Core Screening Department. As a Scientist 2 in the Preclinical department, you will be responsible for planning, executing, and analysing data generated from high-throughput compound screens and CRISPR-Cas9 functional genomic screens for fee-paying commercial clients. Your daily activities will directly align to and benefit Revvity's goals and values.
Key Responsibilities- Contribute to the planning and delivery of arrayed compound screening projects, and pooled functional genomics screening projects, with appropriate supervision, where required.
- Design, QC and analyse high throughput arrayed compound screening projects.
- Manage compound arrayed screening activities in coordination with cell culture, compound management and automation scientists to ensure timely delivery of projects.
- Prepare client reports and support client project tracking and communication in collaboration with the project management office.
- Supervise more junior team members, mentoring them in techniques and troubleshooting problems.
- Contributing to continuous improvement of screening processes and workflows to maximise effectiveness and reduce costs.
- Higher level degree (e.g. MSc, MRes or PhD) in Biotechnology or Biological discipline (or equivalent experience).
- Experience of mammalian cell culture, excellent aseptic technique and performing various cell-based assays, such as those commonly employed at Revvity.
- Experience of handling large datasets and the interpretation and communication of these data to key internal and external stakeholders.
- Excellent interpersonal and communication skills, both written and verbal.
- Flexibility, adaptability, and ability to work in a dynamic matrix-managed team environment and on multiple projects with constantly changing priorities and deadlines.
- Excellent planning/organizational skills with a careful and meticulous nature.
- Ability to perform multiple tasks simultaneously, keep accurate records, follow and give instructions, and comply with company policies.
- Experience with transfection, transduction and techniques to modulate gene expression in mammalian cell models e.g. CRISPR-Cas9, siRNA, shRNA etc.
- Safe handling and production of lentiviral reagents.
- Familiarity with data visualisation software such as Prism and Tibco Spotfire.
- Knowledge of molecular biology techniques such as DNA extraction and PCR.
- Experience of high throughput screening and knowledge of combination screening, including analysing and interpreting compound dose response experiments.
- Knowledge of lab information management systems (LIMS) and liquid handling robotic equipment (although full training will be provided).
- Experience working in an Industrial / CRO setting.
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