Biophysical Scientist

2 weeks ago

Cambridge, Cambridgeshire, United Kingdom Nxera Pharma Full time
About the Role

We are seeking a highly motivated and enthusiastic scientist specializing in biophysical analysis of proteins by surface plasmon resonance (SPR) to join our Protein Sciences group at our research facility.

This is an excellent opportunity for a biophysical scientist to play a key role in drug discovery projects at Nxera Pharma. We apply biophysics in small-molecule drug discovery from hit ID to clinical candidate.

Key Responsibilities
  • Deliver quantitative biophysical analysis on protein-ligand binding (small molecules and other drug modalities) using surface plasmon resonance (SPR). This will include affinity and kinetic data to inform chemical design and mechanistic understanding.
  • Generate high-fidelity and reproducible data and insights into the molecular mechanism of lead compounds and drug candidates.
  • Conduct fragment and other compound screens, validate and characterize hits from these screens to inform design.
  • Identify and drive improvements and innovations in SPR-related techniques (or similar) to expand the scope of biophysical approaches currently employed at Nxera Pharma.
  • Collaborate with various Nxera Pharma scientists on research projects that successfully advance membrane protein targets through the Nxera Pharma structure-based drug design pipeline.
  • Prepare and effectively present results (written and oral) to project teams.
Requirements
  • Masters Degree and/or PhD in Biochemistry/Biophysics or a related discipline with proven and demonstrable SPR experience in a drug discovery environment.
  • Expertise in challenging and innovative characterization of molecular interactions and mechanistic insights using SPR.
  • Experience in other biochemical and biophysical methods such as nDSF, NMR or quantitative mass spectrometry would be considered an advantage.
  • Previous experience with membrane proteins would be desirable.
  • Have strong interpersonal skills and the ability to interact effectively with collaborators from various disciplines.
About Us

Nxera Pharma is a technology-powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs globally.

We employ over 350 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and are listed on the Tokyo Stock Exchange.

We are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies.

Our pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases.

We leverage the power of our unique and industry-leading GPCR-targeted structure-based drug discovery "NxWave" platform to provide a sustainable source of best- or first-in-class candidates.

We have built outstanding capabilities across our platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development.

We are passionate about improving the quality of life and health of people around the world and believe we can achieve our mission through providing a supportive, motivational, and empowering environment for employees.

We are proud to offer a collaborative, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance.

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