Associate Principal Scientist

15 hours ago

Slough, United Kingdom Lonza Full time
United Kingdom, Slough

Associate Principal Scientist

Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

An exciting opportunity has arisen for an ambitious Associate Principal Scientist with extensive and proven experience in the use of Mass Spectrometry (LC MS/MS) for protein characterisation to join our outstanding team at Lonza. The role is based in Slough (UK) and is pivotal to our ongoing success and growth. As an Associate Principal Scientist you will provide oversight and execute analytical studies by developing methodology and interpreting complex datasets. You will be expected to work on complex customer and in-house projects to deliver innovative solutions to technical challenges following all safety and quality procedures.

You will collaborate with peers across teams to ensure meticulous execution of projects and proactively identify and implement technical and operational improvements. This role offers an outstanding chance to input into significant scientific advancements.

Key responsibilities:

  • To lead major or complex work/projects simultaneously while ensuring scientific objective and timelines are met by improving efficiency of current methodology and developing new solutions
  • To work independently and be able to identify and implement innovative LC MS/MS solutions for characterization of biotherapeutic proteins
  • Provide support and mentoring to junior colleagues with planning, execution, troubleshooting of project stages and encourage development of MS users and system owners
  • Communicate with external customers to demonstrate Lonza’s scientific credibility and grow relationships
  • Lead operational improvements and communicate project outcomes to relevant stakeholders
  • Input into department technology strategy based on industry trends and support the Characterisation team in maintaining offerings in line with industry and regulatory expectations
  • Execution of assigned assays with a focus on safety, quality, timeliness and accuracy adhering to regulatory requirements, where appropriate
  • Complete and peer review laboratory documentation
  • Performing technical review of assays to support reference standard and biochemical comparability studies ensuring results reported are scientifically sound and generated in line with current regulatory guidance and expectations
  • Maintenance of analytical equipment, technologies and/or systems required to support characterisation stages
  • Deliver practical training and actively participate in scientific discussions

Key requirements:

  • Extensive and proven experience in developing and troubleshooting analytical methodology for protein analysis with key focus on Mass Spectrometry
  • Familiarity with a range of mass spectrometry platforms such as Quadrupole Orbitrap MS, Tribrid Orbitrap MS or Q ToF MS
  • Proven record of leading method development projects for protein analysis including experimental design, execution and interpretation of complex datasets
  • Experience with a range of analytical methods for protein characterisation such as liquid chromatography (e.g RP, SEC, HILIC), capillary electrophoresis and LC MS/MS
  • Theoretical knowledge of protein chemistry and protein structure (primary and higher order structure)
  • Capability to critically analyse data, interpret results and communicate outcomes to external customers and internal stake holders
  • Proven track record of being able to develop the skills of junior colleagues, particularly with respect to providing guidance and training in the use of LC-MS/MS techniques
  • Excellent communication skills for customer interactions and training
  • Outstanding problem-solving skills and the ability to think creatively and strategically

Join Lonza AG and be part of a team where your contributions will resolve future of life sciences and make a genuine impact on the world.

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Reference: R64145

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