Senior Technical Specialist

3 days ago


Hoddesdon, United Kingdom Pharmaron Full time

**LOCATION: HODDESDON (UK) - Hybrid Working**

We offer:

- **Vibrant and dynamic employment - **we are a highly specialised, growth company operating in a critical sector of the economy - our future is strong and exciting
- **Opportunities to develop your skills and yourself - **our rapid growth brings greater opportunities for you to learn and grow faster
- **A great team where we all support each other - **enjoy your work - after all you spend about a third of your time here

**Our Company**:"We are a dynamic, fast-growing company, with an enviable reputation for leading edge science, offering contract research services to some of the world's leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges".

We believe in our ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for our clients, always operating ethically and with integrity. We take pride in our professionalism and commitment to always deliver our very best work.

We are based in Hertfordshire, in the town of Hoddesdon. The Hoddesdon campus, consisting of several purpose built scientific and administrative buildings together with a purpose built conference STE area has more than 5,000m2 of premier R&D space and houses an established Process Chemistry, Analytical Chemistry and Drug Discovery team, and a newly formed Formulation Development department. The Hoddesdon site has state-of-the-art Good Manufacturing Practice (GMP) standard facilities for the development of Active Pharmaceutical Ingredients (API), formulation development and process chemistry. We offer our employees a highly supportive team-work environment, enabling them to develop and liberate their true potential.

**Job Title: Senior Technical Specialist - LC-MS Bioanalysis**

**Job Summary**

We have opened a new Bioanalysis group at the Hoddesdon site to complement our work at Rushden. This team will work closely with the newly formed in vitro DMPK Assay group at Hoddesdon.

The Pharmaron Team is looking to expand and recruit a Discovery Bioanalysis Senior Scientist / Technical Specialist with strong experience of developing LC-MS methods for the quantitative measurement of small molecules.

**Key Roles and Responsibilities**:

- Developing bioanalytical LC-MS methods for small and large molecules in discovery phase studies with rapid turnaround times, for subsequent assay qualification and sample analysis.
- Act as study supervisor on discovery phase studies
- Provide analytical support for in vitro DMPK assays with rapid turnaround times.
- Providing analytical trouble shooting support as required.
- Training and mentoring less experienced staff in method development and operation of mass spectrometers.
- Ensuring work is conducted, documented, and reported in line with department practices and governing policies, and with client requirements where appropriate.
- Identifying new technologies, which could be of significant benefit to the group, improving capability or reducing operational costs.
- Increasing the profile of the department externally through playing an active role in expert groups, networking, and publications.

**Essential Requirements**:

- Demonstrated experience with small and/or large molecule LC-MS method development, validation and troubleshooting in a CRO or Pharmaceutical Company.
- Extensive experience ( >5 years) of quantitative triple quadrupole mass spectrometry (Sciex triple quadrupole platforms) paired with liquid chromatography (e.g., Agilent systems)
- Extensive experience in the development of sample extraction and work-up methods. Experience of automation platforms (e.g., Hamilton, Tecan) advantageous
- Proficient in the use of relevant software e.g., Analyst, Watson, WinNonLin.
- Good understanding of the regulated bioanalysis guidelines.
- Understanding of the drug development process.
- Scientific data interpretation, reporting and presentation skills.
- Coaching & Mentoring.

**Why Should You Apply?**
- This is an opportunity for you as a successful LC-MS specialist to be a highly valued member of our team and have a real impact in a fast-growing and highly respected CRO striving to become the world leader in contract research services.
- Build and shape your career in an environment that sets and commits to the highest standards of scientific research.
- To be part of a team who support each other, embrace and solve technical challenges and put excellence at the heart of all that we do.
- Pharmaron is a premier R&D service company supporting the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities having established diverse drug R&D service capabilities, ranging from synthetic, medicinal and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry and isotopically labelled metabolism, chemical & pharmaceutical development to clinical development. With operations in China, US and UK



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