Postdoctoral Research Associate

5 months ago

Didcot, United Kingdom Diamond Light Source Full time

**About Us**

Diamond Light Source is the UK’s national synchrotron science facility. By accelerating electrons to near light-speed, Diamond generates brilliant beams of light from infra-red to X-rays which are used for academic and industry research and development across a range of scientific disciplines including structural biology, physics, chemistry, materials science, engineering, earth, and environmental sciences.

**About the Role**

The XFEL Hub and our collaborators conduct research and development at the forefront of serial and time-resolved macromolecular crystallography. We also work to transfer those techniques that are complementary and synergistic between XFELs, synchrotrons, and cryo-EM, and/or electron diffraction (ED). Our research and development efforts cross several fronts in biophysics from enzyme kinetics to various types of spectroscopies and includes a variety of serial crystallography experiments at Diamond Light Source and all hard X-ray XFEL facilities around the world. Our science drivers include heme and non-heme metalloenzymes that use Fe, Cu, and/or Ni ions or clusters to facilitate catalysis of a wide range of energetically difficult reactions in biology.

We define dynamic structural biology as a philosophy as well as a set of tools to collect as much data as possible, from every sample and every X-ray pulse, at physiological temperature and pressure, with an aim to create time-resolved, stop-motion, molecular movies of macromolecules engaged in function. One of our over-arching objectives is to create routine and robust strategies that exploit microcrystal slurries for time-resolved studies at XFELs and storage rings like Diamond’s VMXi and I24 beamlines. Many of our research and development efforts include large, international collaborations with significant interactions at the University of Oxford and other UK universities, Lawrence Berkeley National Laboratory, and XFEL facilities in the USA, Japan, Korea, Germany, and Switzerland.

Duties include:

- Contributing to the research and development (R&D) activities in dynamic structural biology of (metallo)enzymes.
- Contributing to the analysis of and publication of scientific results in international peer-review journals.
- Keeping up to date with the latest results and evolving methods for structural biology at leading synchrotron and XFEL sources, especially with respect to sample delivery and/or time-resolved strategies.
- Dependable participation in large, international collaborative teams with diverse backgrounds

**About You**

You will hold an PhD in biochemistry, chemistry, biophysics, or related engineering field(s) as well as experience in the use of scientific instrumentations and data collection.

XFEL experience in time-resolved structural biology and/or spectroscopy is highly desirable, but not essential.

**Benefits**

Diamond offers an exceptional benefits package to support staff in achieving a positive work/life balance. This includes 26 days annual leave plus Christmas closure, public holidays, 2 annual volunteering days and flexible working hours. We also offer an excellent defined benefit pension scheme. Staff also have access to a range of amenities on site including a nursery, cafes, a restaurant and sports and leisure facilities. A relocation allowance may also be available where applicable.

**To Apply**

Other information
- Further company benefits
- Life at Diamond
- Nuvos Pension Scheme

Diamond is open to different ways of working and we are committed to supporting our employees to have more flexibility and autonomy over where, when and how long they work.

Where relevant, and possible for the role, we will consider flexible working arrangements, secondment and job share opportunities.

Diamond are members of Working Families (the UK’s work-life balance organisation), we have also achieved the Athena SWAN Bronze award and Disability Confident Level Two.

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