Clinical Research Fellow

1 month ago

Edinburgh, United Kingdom University of Edinburgh Full time

**Clinical AMN2 Scale - £43,504 - £64,461**

**Deanery of Clinical Sciences/Institute for Regeneration and Repair/Centre for Inflammation Research**

**Contract Type - Fixed Term - 3 Years**

**Full Time - 35 Hours Per Week
A Clinical Fellow position is available for a three-year Research Fellowship (to count towards a PhD higher research degree) with Professor Neil Henderson within the Centre for Inflammation Research at the University of Edinburgh.

**The Opportunity**:
Currently, therapeutic options for patients with chronic liver disease are limited to removal of the underlying cause, if possible, and transplantation reserved for a select few. Importantly, the degree of liver fibrosis predicts adverse clinical events including clinically significant portal hypertension, hepatic decompensation and the development of hepatocellular carcinoma. Therefore, developing effective anti-fibrotic therapies for patients with chronic liver disease is likely to impact significantly on morbidity and mortality, and hence, the discovery of effective anti-fibrotic therapies remains one of the holy grails in hepatology.

Single-cell RNA sequencing (scRNA-seq) has the potential to deliver a step change in both our understanding of healthy liver tissue homeostasis as well as disease pathogenesis, such as NASH-induced liver fibrosis and cirrhosis, allowing the interrogation of individual cell populations at unprecedented resolution. In this project, the Fellow will use and be trained in a broad range of cutting-edge single cell genomics techniques including single cell and single nuclei RNA sequencing (10X Genomics Platform) of freshly isolated cells from human liver tissue (uninjured and explant tissue obtained at time of liver transplantation), spatial transcriptomics, multi-colour flow cytometry/cell sorting, confocal microscopy, and human liver fibrosis imaging approaches (eg PET-based Tracer / MRI liver imaging in patients with chronic liver disease).

Application of new single cell genomics and PET-based imaging approaches in chronic liver disease should greatly facilitate the discovery of novel, rational therapeutic targets and pathways to treat patients with liver fibrosis. This work should also inform molecular pathology-based patient stratification, which is fundamental to the prosecution of successful clinical trials in human liver fibrosis.

Henderson Lab webpage (opens new browser tab)

**Your skills and attributes for success**:

- GMC registration
- Interest in a career in academic medicine
- Ability to interface and work with multi-disciplinary teams across science and medicine Applicants must be willing to work in an interdisciplinary environment and develop new skills.

**Click to view a copy of the full **job description **(opens new browser tab).

**As a valued member of our team you can expect**:
An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits **pension scheme **, **staff discounts, **family friendly initiatives **, flexible working and much more. Access our **staff benefits page **for further information and use our **reward calculator **to find out the total value of pay and benefits provided.

**Championing equality, diversity and inclusion**:
The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

**Key notes for applicants**:
Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our **right to work webpages **(opens new browser tab)

An Honorary NHS contract will be sought for the successful post holder. You therefore must be eligible to hold an honorary contract with NHS Lothian, and must also be registered with the General Medical Council.

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