Advanced Research Assistant

3 weeks ago

Cambridge, United Kingdom Wellcome Sanger Institute Full time

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.

We are looking for a talented individual to join the Cellular Operations (CellOps) division as part of the Gene Editing team on a full-time, permanent basis. You will be working as part of a diverse group using advanced gene editing technologies to deliver functional genomics projects in partnership with Faculty teams.

Please note: Participation in weekend/public holiday rota may be required.

**About the Role**:
The Gene Editing team uses bespoke gene editing approaches to generate novel cell lines and create high-quality genome engineering resources for our Faculty partners. The role of an ARA is a laboratory-based position, where you will:

- Independently design, perform and validate genome engineering experiments to edit HiPSC and mammalian cell lines
- Maintain accurate records through Electronic Lab Notebooks and project management tools
- Contribute to the timely analysis, review and reporting of data. Proactively troubleshoot and report any issues
- Support the day-to-day organisation of the laboratory, including inventory management, cleaning rota's and supporting 5S initiatives
- Contribute to writing and updating SOPs and risk assessments. Work in accordance with the H&S guidelines
- Promote a culture of continuous process improvement, open communication, creativity and inclusion

As signatories of the Technician Commitment, we value the personal growth and recognition of our dedicated staff. As part of this role, you will be actively encouraged to take part in learning and development opportunities, public engagement and department-wide initiatives. We have a number of working groups available to join, such as the communication group, which aims to effectively promote our work across the Institute and externally.

In addition, we are driven by a culture of inclusion, which means you will be fully supported to engage with the various staff networks or take part in any Institute-wide initiative.

**About You**:
To excel in this role, will need the following skills and experience:

- A proactive, self-organising individual, enthusiastic about the delivery of biological resources to support genomic research.
- Experienced in mammalian cell culture and molecular biology, capable of troubleshooting your work and disseminating results to a wide range of individuals.
- Highly motivated to stay up-to-date with the latest technologies and implement new methods to ensure that we continue to support cutting-edge research.

We function in a collaborative environment, with projects spanning multiple faculty and core facility groups. Hence, you must excel at working in diverse, collaborative teams and be able to work effectively in a matrix-managed setting.

**Required Skills**:

- Degree in Biological Sciences or related discipline with 1-3 years of relevant laboratory experience
- Extensive experience with culturing mammalian cell lines
- Strong theoretical understanding of CRISPR/Cas technology and cell line generation
- Practical molecular biology skills, including the use of molecular biology software and online tools
- Excellent interpersonal skills with the ability to work well with others in a dynamic and highly collaborative environment
- Strong communication skills, confident in disseminating information to various audiences
- Ability to maintain accurate records and report progress
- Proven ability to be able to work independently, organise and schedule individual workloads
- Experience in troubleshooting, protocol development and implementing new strategies

**About us**:
CellOps is a core research group, responsible for providing molecular and cell biology resource and expertise to the wider Institute. We do this by running an array of high-throughput projects for Faculty teams across the Sanger Institute. Our current portfolio of projects includes the generation of CRISPR-edited cells, saturation genome editing, iPSC differentiation,, organoid derivation and Spatial Genomics.

Further information about Cellular Operations, and the Institute's involvement in the Technician Commitment, can be found on our website:
**Application Process**:
Please include a cover letter along with your CV. In your cover letter include your understanding of what is required for an effective gene editing core facility. Also, include details on how your knowledge and experience will contribute to this.

Interviews are expected to take place week commencing 18th September 2023

**Other Information**:
**Salary**:£31,700 to £38,000 dependent upon skills and experience

**Working at Wellcome Sanger**:
Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

**Our Benefits**:
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

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