Research Assistant

3 weeks ago

London, United Kingdom King's College London Full time

Job description

Overview

We are looking for an experienced chemistry technician to support our multi-disciplinary team. We are based in the Centre for Craniofacial and Regenerative Biology at King’s College London in central London, just steps away from London Bridge station.

Research Aims

Person Specifications
- Experience performing chemical syntheses using synthetic (e.g. PEG) and/or naturally derived polymers (e.g. hyaluronic acid)
- Experience preparing samples for NMR and interpreting data
- Experience performing HPLC/SEC/MS
- Good understanding of polymer chemistry
- Good understanding of peptide chemistry and peptide design
- Experience performing general chemistry laboratory maintenance, including handling gas cylinders and liquid nitrogen

Key responsibilities include:

- Creating stocks of hydrogel components by performing chemical syntheses to modify hyaluronic acid with methacrylate, vinyl sulfone, thiol or other reactive groups
- Preparing modified hyaluronic acid for NMR analyses
- Creating stocks of PEG hydrogel components by performing reactions to conjugate peptides to PEGs
- Optimising reaction conditions to conjugate new peptides to PEG
- Purifying PEG-peptide conjugates and performing characterisation/quality control experiments using NMR, HPLC, and SEC
- Maintaining laboratory equipment and stocks of general reagents for chemistry work, including working with suppliers to provide custom-synthesised reagents
- Supporting additional work in the laboratory, including mammalian cell culture, flow cytometry, immunostaining, confocal microscopy, histology, western blot, ELISA, rheology, and qPCR.

This full-time post is funded for 25 months, in the first instance.

This post will be offered on an a fixed-term contract for 25 months

This is a full-time post - 100% full time equivalent

Key responsibilities
- Creating stocks of hydrogel components by performing chemical syntheses to modify hyaluronic acid with methacrylate, vinyl sulfone, thiol or other reactive groups
- Preparing modified hyaluronic acid for NMR analyses
- Creating stocks of PEG hydrogel components by performing reactions to conjugate peptides to PEGs
- Optimising reaction conditions to conjugate new peptides to PEG
- Purifying PEG-peptide conjugates and performing characterisation/quality control experiments using NMR, HPLC, and SEC
- Maintaining laboratory equipment and stocks of general reagents for chemistry work, including working with suppliers to provide custom-synthesised reagents
- Supporting additional work in the laboratory, including mammalian cell culture, flow cytometry, immunostaining, confocal microscopy, histology, western blot, ELISA, rheology, and qPCR.
- The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post._

Essential criteria
- Experience performing chemical syntheses using synthetic (e.g. PEG) or naturally derived polymers (e.g. hyaluronic acid)
- Experience preparing samples for NMR and interpreting data
- Experience performing HPLC/SEC
- Good understanding of polymer chemistry
- Good understanding of peptide chemistry and peptide design
- Experience performing general chemistry laboratory maintenance, including handling gas cylinders and liquid nitrogen

Desirable criteria
- Experience working with biological hydrogels
- Experience with mammalian cell culture
- Experience performing gene expression analyses by qPCR
- Experience using confocal microscopy
- Experience using atomic force microscopy
- Experience performing western blot
- Experience performing measurements using rheological techniques

Key responsibilities
- Creating stocks of hydrogel components by performing chemical syntheses to modify hyaluronic acid with methacrylate, vinyl sulfone, thiol or other reactive groups
- Preparing modified hyaluronic acid for NMR analyses
- Creating stocks of PEG hydrogel components by performing reactions to conjugate peptides to PEGs
- Optimising reaction conditions to conjugate new peptides to PEG
- Purifying PEG-peptide conjugates and performing characterisation/quality control experiments using NMR, HPLC, and SEC
- Maintaining laboratory equipment and stocks of general reagents for chemistry work, including working with suppliers to provide custom-synthesised reagents
- Supporting additional work in the laboratory, including mammalian cell culture, flow cytometry, immunostaining, confocal microscopy, histology, western blot, ELISA, rheology, and qPCR.
- The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post._

Essential criteria
- Experience performing chemical syntheses using synthetic (e.g. PEG) or naturally derived polymers (e.g. hyaluronic acid)
- Experience preparing samples for NMR

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