Research Scientist

3 weeks ago

Cambridge, United Kingdom REED Engineering Full time

**Scientist/Research Scientist - Protein Engineering**
**Permanent, Full-Time**
**Cambridge area, UK**

REED Scientific are working with an international biopharmaceutical company who discover, design, and develop some of the most innovative and effective medicines for patients worldwid**e.**

**About the Job**

They are searching for a molecular biologist to join the Protein Engineering group working on GPCR structure determination to enable drug discovery efforts.

**In this role you will be responsible for**:

- Cloning of plasmid constructs for expression;
- Expression of GPCRs in insect, yeast and human cells;
- Characterization of GPCRs in membranes and in detergent-solubilised form using ligand binding assays;
- Establishing and optimising thermal stability assays;
- Mutant library generation and directed evolution of proteins;
- Screening for stabilising mutations using our proprietary platform to create StaR® proteins;
- Construct engineering to optimise expression;
- Purification and biochemical characterisation of GPCRs using a range of techniques such as size exclusion chromatography;
- Optimising expression of other membrane proteins (e.g., ion channels and transporters)
- Careful documentation of experimental work; and,
- Work closely with molecular biologists, protein expression scientists, biophysicists, structural biologists, and pharmacologists to help advance the project.

**Skills/experience**:

- BSc or MSc in a relevant area of biology
- Ability to work flexibly within a team, whilst being highly self-motivated and able to work independently;
- Analytical thinking and good problem-solving skills;
- Excellent organisational and time-management skills, including the ability to work to strict deadlines;
- Fluency in oral and written English is essential; and
- Relevant lab experience would be preferred including:

- Experience in cloning techniques;
- Proficient in cell culture techniques for the expression of proteins in mammalian, insect or yeast cells;
- Experience in protein purification;
- Experience of assay development and optimisation;
- Experience in flow cytometry;
- Experience in GPCR _in vitro_ pharmacology and GPCR biochemical assays would be desirable.

This is a one-of-a-kind opportunity to join a burgeoning company, and work using state-of-the-art scientific equipment and facilities.

If this sounds of interest and you meet the requirements, don’t miss this opportunity

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