Senior Research Associate

2 weeks ago


Lancaster, United Kingdom Lancaster University Full time

Postdoctoral Research Associate: DNA damage-induced innate immunity in bladder cancer

We are looking for a highly motivated and creative individual to join us as a post-doctoral researcher within the group of Dr Leonie Unterholzner in the Division of Biomedical and Life Sciences at Lancaster University, to investigate the innate immune response during chemo
- and radiotherapy in bladder cancer.

Our lab is interested in how DNA sensors detect cytosolic DNA and nuclear DNA damage in human epithelial cells (Dunphy et al., Mol Cell, 2018; Almine et al., Nat Comms, 2017). This CRUK-funded position is part of a collaboration between the Unterholzner lab at Lancaster University and Prof Ananya Choudhury at The Christie NHS Foundation Trust and the Division of Cancer Sciences University of Manchester. In this project, we will investigate the molecular mechanisms that govern the detection of DNA damage induced by radio
- and chemotherapy by the innate immune signalling hub STING, and the subsequent innate immune signalling profiles which may have pro
- or anti-tumour functions.

This is a fixed term position for a period of 34 months.

The Division of Biomedical and Life Sciences, within the Faculty of Health and Medicine at Lancaster University, is a rapidly growing Division whose research effort is directed towards understanding basic cellular and physiological mechanisms that underpin disease states. It provides a friendly research environment that strongly supports the individual needs of each employee and which actively promotes a healthy work-life balance. The Faculty is committed to family-friendly and flexible working policies and has held a Silver Athena SWAN award since 2014 in recognition of its good employment practice undertaken to address gender equality in higher education and research.



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