Research Associate/fellow

3 weeks ago


Nottingham, United Kingdom University of Nottingham Full time

**School of Medicine, Translational Medical Sciences**:
**Location**:

- University Park**Salary**:

- £30,487 to £34,980 per annum (pro rata if applicable) depending on skills and experience (minimum £33966 with relevant PhD).**Closing Date**:

- Thursday 14 March 2024**Reference**:

- MED018424The project, funded by Accession Therapeutics, will study the infectivity of a novel viral immunotherapeutic agent called TROCEPT in fibrotic lung tissue utilising precision cut lung slices as a 3D culture model. Accession Therapeutics’ proprietary technology incorporates cancer-tropic viruses, the first time that viruses have been genetically modified to exclusively target cancer cells. This project forms part of the further preclinical development of TROCEPT and aims to thoroughly investigate the ability of TROCEPT to infect fibrotic lung tissue.

The successful role holder will utilise precision cut lung slices to study TROCEPT infectivity. PCLS are an ideal tissue-based model as they are comprised of all structural cells found within the lungs and maintain normal cell-cell and cell-matrix interactions. The role holder will be responsible for initial model optimisation for use in viral infection studies and will utilise end point analyses including immunohistochemistry/immunofluorescence, qRT-PCR and western blotting. This post will be based within the laboratory group of Dr Amanda Tatler, who has extensive experience of using PCLS to study respiratory diseases, including those of a fibrotic nature. The role holder will be responsible for carrying out laboratory research, data analysis and presentation of results both internally within the University and externally to Accession Therapeutics.



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