Postdoctoral Research Associate

3 weeks ago

Edinburgh, United Kingdom University of Edinburgh Full time

**UE07 £35,333 - £42,155**

**College of Science and Engineering, School of Biological Science, Institute for Stem Cell Research**

**Fixed Term; 18 Months**

**Full time; 35hrs per week**

We are looking for a post-doctoral research scientist to determine how pluripotency transcription factors control gene transcription.

**The Opportunity**:
This post will analyse the role of pluripotency transcription factors in modulating gene expression in mouse embryonic stem cells. By combining CRISPR/Cas9 and chromatin approaches, the post holder will target a select subset of putative enhancers bound by pluripotent transcription factors, singly and in combination with the goal of identifying regulatory elements that drive the self-renewal/differentiation capacity of embryonic stem cells.

Successful applicants will have a keen interest in how cell identity is determined.

**Your skills and attributes for success**:

- PhD in an appropriate biological science
- Expertise in stem cell culture
- Experience in CRISPR/Cas9-based genome manipulation
- Ability to communicate complex information clearly, orally and in writing

Click **here **for a copy of the full job description

**As a valued member of our team you can expect**:
An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits **pension scheme **, **staff discounts, **family friendly initiatives **, flexible working and much more. Access our **staff benefits page **for further information and use our **reward calculator **to find out the total value of pay and benefits provided.

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

If invited for interview you will be required to evidence your right to work in the UK. Further information is available on our **right to work **webpages.

As a world-leading research-intensive University, we are here to address tomorrow’s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.

The Centre for Regenerative Medicine (CRM) is a world-leading research centre bringing together 19 research groups led by non-clinical and clinician scientists working in both basic and clinical research to study stem cells, disease and tissue repair to advance human health. Our research is aimed at developing new treatments for major diseases including cancer, heart disease, diabetes, degenerative diseases such as multiple sclerosis and Parkinson's disease, and liver failure. The Centre was awarded MRC Centre status in 2008, with the mission being to gain fundamental understanding of stem cells and regeneration and to use this knowledge to improve human health and provide leadership in training and in public engagement. The Centre is housed in a purpose-built new facility, the £54M Scottish Centre for Regenerative Medicine, based at Edinburgh’s Little France hospital campus, which has enabled co-location of the School’s Institute for Stem Cell Research with scientists in Medicine & Veterinary Medicine. The new building offers a dynamic and interactive environment with excellent in-house facilities. Research is funded by the MRC, BBSRC, the Wellcome Trust, the Leukaemia Research Fund, the Juvenile Diabetes Research Foundation, the Human Frontiers Science Program Organisation and other agencies.

As well as creating a vibrant and cohesive scientific community, this move complements the close interactions with colleagues in other parts of the School of Biological Sciences, notably the Institute of Cell Biology (including the Wellcome Trust Centre for Cell Biology) and the Institute of Structural and Molecular Biology, by enabling us also to tap into strengths on the medical campus that include a teaching hospital, a Wellcome-funded clinical research facility, and a Wellcome and MRC-funded human research imaging facility. Internationally we have strong collaborative interactions with the RIKEN Centre for Developmental Biology in Japan and we are a major partner in the European Consortium for Stem Cell Research, EuroStemCell, an FP6 integrated project.

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