Postdoctoral Research Fellow

1 month ago


Edinburgh, United Kingdom University of Edinburgh Full time

**UE07 £37,099 - £44,263**

**Full time 35 hours per week**

**Fixed term
We are seeking an independent and highly motivated Postdoctoral Research Fellow for a project funded by DRI exploring cerebral Small Vessel Disease (SVD), and focussing on lipid metabolism. The post is funded through the Edinburgh Dementia Research Centre in the UK MRC Dementia Research Institute.

**The Opportunity**:
This preclinical research project will study lipid biology in SVD, using rat models and human tissue. Our transgenic rat model of SVD has a global knock out of _Atp11b _, which is a phospholipid flippase. This flips the phospholipids PS and PE from the outer surface of a membrane to the inner, and so we expect this to be key in maintaining membrane function and the secretory pathways of the cells expressing it. This project will examine this mechanism in brain endothelial cells and in the model rat to understand more about the role of ATP11B in SVD. This project will use lipidomic, biochemical and cell biology techniques. We expect this original research to produce material for high impact publications, grant proposals and dissemination.

**Your skills and attributes for success**:

- PhD in biological sciences /neuroscience /cell or molecular biology, or related field. (Obtained or submitted)
- Expert knowledge, previous use and considerable practical experience of lipid biology techniques required.
- Expertise in analysis of lipidomic/proteomic/transcriptomic datasets.
- Strong theoretical and practical knowledge in cell biology, and molecular biology, including cell culture, immunohistochemistry, in situ hybridisation, confocal microscopy.
- Experience of working with in vivo animal models and human tissue. Hepatitis B vaccination.

**Click to view a copy of the full **job description
**As a valued member of our team you can expect**:

- A competitive salary of £37,099 to £44,263.
- An exciting, positive, creative, challenging and rewarding place to work.
- To be part of a diverse and vibrant international community.
- Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our **staff benefits page **and use our reward calculator to discover the total value of your pay and benefits.

**Championing equality, diversity and inclusion**

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our **right to work webpages**

The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant.

**Key dates to note**:
It is anticipated that interviews will be held in December 2023.



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