Joint University of Cambridge/astrazeneca Phd

2 weeks ago


Cambridge, United Kingdom University of Cambridge Full time

An opportunity exists for a graduate student to undertake a PhD starting in October 2023 under the supervision of Dr Brian Ferguson and Dr Gunnel Hallden developing and testing novel oncolytic viruses based on vaccinia virus. This joint project will exploit the Ferguson lab's expertise in anti-viral innate immunity and experience in generation of recombinant poxviruses with the resources and backing of the oncolytic virotherapy team at Astra Zeneca lead by Dr Hallden. The project will aim to generate a range of novel oncolytic recombinant vaccinia viruses and test them in vitro, in organoids and in animal models of cancer. A range of techniques will be used to generate viruses, assess their efficacy in murine tumour models, and analyse the innate and cellular immune responses during treatment.

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